MiRNAs and their association with locoregional staging and survival following surgery for esophageal carcinoma

Annals of Surgical Oncology
Richard HummelDavid I Watson

Abstract

Prognostic and staging information for esophageal cancer impacts clinical decision making. miRNAs, a newly discovered class of biomarkers and their expression might add additional information relevant to this. In this study we evaluated the expression of selected miRNAs and their relationship to tumor stage and survival in patients with locally advanced tumors following esophagectomy. A total of 43 individuals undergoing esophagectomy (without neoadjuvant therapy) for locally advanced but not metastatic (pT2/3; pN0/1) disease (22 adenocarcinoma [EAC], 21 squamous cell carcinoma [SCC]) were included in this study. Perioperative clinical and survival data were collected and managed on a database. The expression of miR-21, miR-106a, miR-148a, miR-205 in formalin-fixed paraffin-embedded specimens was evaluated by TaqMan qPCR assays. Expression was compared with clinicopathological features of the cancers and outcome. In EAC, miR-148a expression levels were inversely associated with cancer differentiation. miR-21 expression levels were higher in SCC if distant lymph node metastases were present. miR-148a levels were lower when EAC was more proximally located, and miR-21 levels were lower when SCC was more proximal. miR-106a and miR-...Continue Reading

References

Jun 10, 2005·Nature·Jun LuTodd R Golub
Oct 28, 2005·The New England Journal of Medicine·George Adrian CalinCarlo M Croce
Sep 23, 2006·Developmental Biology·Baohong ZhangTodd A Anderson
Oct 31, 2006·Trends in Molecular Medicine·Ramiro GarzonCarlo M Croce
Nov 24, 2006·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Nobuyoshi SugitoYoshitaka Fujii
Apr 7, 2007·Pediatric Research·Jody C Chuang, Peter A Jones
Apr 20, 2007·Retrovirology·Amy M LumMatthias Wabl
Sep 27, 2007·Molecular Cancer·William C S Cho
Nov 29, 2007·APMIS : Acta Pathologica, Microbiologica, Et Immunologica Scandinavica·Jack B CowlandKirsten Grønbaek
Jan 31, 2008·JAMA : the Journal of the American Medical Association·Aaron J SchetterCurtis C Harris
Feb 5, 2008·The Journal of Thoracic and Cardiovascular Surgery·Andrew FeberVirginia R Litle
Mar 29, 2008·Cancer Gene Therapy·A W Tong, J Nemunaitis
May 2, 2008·International Journal of Cancer. Journal International Du Cancer·Lin XiaDaiming Fan
Jun 4, 2008·Genes, Chromosomes & Cancer·Raquel DíazGemma Domínguez
Jul 23, 2008·Molecular Cancer Therapeutics·Olga KovalchukIgor P Pogribny
Sep 5, 2008·Proceedings of the National Academy of Sciences of the United States of America·Amaia LujambioManel Esteller
Nov 11, 2008·Clinica Chimica Acta; International Journal of Clinical Chemistry·Bingxiu XiaoJiuchang Zhong
Dec 3, 2008·Biological Reviews of the Cambridge Philosophical Society·Niamh Lynam-LennonJohn V Reynolds
Jan 30, 2009·Journal of Gastroenterology and Hepatology·Junming GuoYanjun Wang
Jan 31, 2009·The American Journal of Pathology·Geoffrey ChildsNicolas F Schlecht
Feb 25, 2009·Gynecologic Oncology·Todd BorenJohnathan M Lancaster
Mar 12, 2009·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Yukiharu HiyoshiHideo Baba
May 14, 2009·Stem Cells and Development·Michaela MerkerovaHana Bruchova
Jun 19, 2009·Medical Molecular Morphology·Ryo OgawaYoshitaka Fujii
Aug 25, 2009·Translational Oncology·Armando MagrelliDomenica Taruscio
Sep 10, 2009·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Hushan YangXifeng Wu
Mar 20, 2010·The British Journal of Surgery·B P L WijnhovenUNKNOWN South Australian Oesophageal Research Group

❮ Previous
Next ❯

Citations

Jul 26, 2012·Expert Opinion on Biological Therapy·Liu HongDaiming Fan
May 15, 2012·Gastroenterology·Jee Hoon Song, Stephen J Meltzer
Oct 21, 2015·Acta Oncologica·Mette WintherMarianne Nordsmark
May 8, 2013·International Journal of Cancer. Journal International Du Cancer·M OdenthalD Vallböhmer
Jun 4, 2013·British Journal of Haematology·Beatriz Sánchez-EspiridiónJuan F Garcia
Jan 26, 2016·Journal of Cellular Biochemistry·Ajay BansalKenneth Wang
Feb 22, 2012·Upsala Journal of Medical Sciences·Gianpiero Di LevaCarlo M Croce
May 27, 2015·Clinical & Experimental Metastasis·Adriana SondermannPatricia Severino
Sep 10, 2013·Seminars in Cancer Biology·Naomi S SakaiRebecca C Fitzgerald
Jul 27, 2014·Biochemical and Biophysical Research Communications·Sifeng TaoWenjie Yue
Jul 30, 2016·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Maryam HemmatzadehBehzad Baradaran
Aug 30, 2011·Biomarkers : Biochemical Indicators of Exposure, Response, and Susceptibility to Chemicals·Su Q LiXiu F Cao
Mar 31, 2012·Diseases of the Esophagus : Official Journal of the International Society for Diseases of the Esophagus·S-Q LiX-F Cao
Jan 20, 2011·Journal of Gastrointestinal Surgery : Official Journal of the Society for Surgery of the Alimentary Tract·Richard HummelDamian J Hussey
Mar 13, 2013·Expert Review of Anticancer Therapy·George C MayneDavid I Watson
Oct 27, 2017·Experimental and Therapeutic Medicine·Quan ChenXiaoying Zhang
Apr 12, 2013·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Alok Kishorkumar ShahMichelle M Hill

❮ Previous
Next ❯

Related Concepts

Related Feeds

Carcinoma, Squamous Cell

Basal cell carcinoma is a form of malignant skin cancer found on the head and neck regions and has low rates of metastasis. Discover the latest research on basal cell carcinoma here.

Cancer Incidence & Mortality

Cancer has emerged as a global concern due to its increase in incidence and mortality. Efforts are underway to evaluate and develop action plans to reduce the global burden of cancer. Currently, lung cancer, breast cancer and prostate cancer are the leading causes of cancer mortality. Here is the latest research on cancer incidence and mortality.

Related Papers

Clinical Cancer Research : an Official Journal of the American Association for Cancer Research
Ewy A MathéCurtis C Harris
Clinical Cancer Research : an Official Journal of the American Association for Cancer Research
Rie HamanoYuichiro Doki
European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)
Feng ZhiYilin Yang
© 2021 Meta ULC. All rights reserved