miRNAs deregulation in serum of mice is associated with lung cancer related pathway deregulation induced by PM2.5

Environmental Pollution
Jie NingRong Zhang

Abstract

Ambient fine particulate matter (PM2.5) as an environmental pollution has been associated with the lung cancer. However, the mechanism of epigenetics such as miRNAs deregulation between PM2.5-exposure and lung cancer has not been elucidated clearly. Twenty C57BL/6 mice were divided randomly into 2 groups and exposed to the filtered air (FA) and the concentrated air (CA), respectively. The FA mice were exposed to filtered air in chambers with a high-efficient particulate air filter (HEPA-filter), and the CA mice were exposed to concentration ambient PM2.5. The total duration of exposure was performed 6 h per day from December 1st, 2017 to January 27th, 2018. The mice exposed 900.21 μg/m3 PM2.5 for 6 h per day in CA chamber, which was nearly equaled to 225.05 μg/m3 for 24-h calculatingly. After exposure, the serum miRNAs levels were detected by microarray. Genetic and pathological alterations in lung of mice with/without PM2.5 exposure were detected. 38 differential miRNAs in serum of mice were found after PM2.5 exposure for 8 weeks. Among of them, 13 miRNAs related with lung cancer were consistent in serum and lung of mice. The target genes of 13 deregulated miRNAs including CRK, NR2F2, VIM, RASSF1, CCND2, PRKCA, SIRT1, CDK6, MA...Continue Reading

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Citations

Mar 29, 2021·Environmental Pollution·Fei QinJiexiu Zhao
Jun 6, 2021·The Science of the Total Environment·Ching-Yu LinTsun-Jen Cheng
Jul 16, 2021·Frontiers in Oncology·Sara PatriziAdamo Pio d'Adamo
Mar 19, 2021·Applied Immunohistochemistry & Molecular Morphology : AIMM·Zhi-Dan HuaZhi-Qiang Han
Sep 10, 2021·Environmental Science and Pollution Research International·Suranjana MukherjeeKoel Chaudhury

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