miRNAs in osteoclast biology.

Bone
Megan M WeivodaDavid G Monroe

Abstract

MicroRNAs (miRNAs) are a class of short RNA molecules that mediate the regulation of gene activity through interactions with target mRNAs and subsequent silencing of gene expression. It has become increasingly clear the miRNAs regulate many diverse aspects of bone biology, including bone formation and bone resorption processes. The role of miRNAs specifically in osteoclasts has been of recent investigation, due to clinical interest in discovering new paradigms to control excessive bone resorption, as is observed in multiple conditions including aging, estrogen deprivation, cancer metastases or glucocorticoid use. Therefore understanding the role that miRNAs play during osteoclastic differentiation is of critical importance. In this review, we highlight and discuss general aspects of miRNA function in osteoclasts, including exciting data demonstrating that miRNAs encapsulated in extracellular vesicles (EVs) either originating from osteoclasts, or signaling to osteoclast from divergent sites, have important roles in bone homeostasis.

References

Aug 1, 1991·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·P T Lakkakorpi, H K Väänänen
Jul 31, 1998·Frontiers in Bioscience : a Journal and Virtual Library·L T Duong, G A Rodan
Sep 24, 2002·Current Molecular Medicine·Gideon A Rodan, Alfred A Reszka
Sep 24, 2002·Seminars in Cell & Developmental Biology·Gudrun Stenbeck
May 16, 2003·Nature·William J BoyleDavid L Lacey
Sep 10, 2003·Endocrinology·Xiaojun WuJay M McDonald
Sep 29, 2004·The Journal of Experimental Medicine·Toshio KukitaHisayuki Nomiyama
Feb 8, 2005·Trends in Molecular Medicine·T John Martin, Natalie A Sims
Aug 3, 2005·The Journal of Experimental Medicine·Mitsuru YagiToshio Suda
Feb 1, 2006·Trends in Genetics : TIG·V Narry Kim, Jin-Wu Nam
Jul 13, 2006·Annals of the New York Academy of Sciences·Henry M Kronenberg
Aug 8, 2006·Cell Metabolism·Chen ZhaoKoichi Matsuo
Nov 14, 2006·Bone·Masataka Asagiri, Hiroshi Takayanagi
Jul 10, 2007·Nature Medicine·Mone Zaidi
Feb 2, 2008·Proceedings of the National Academy of Sciences of the United States of America·Tatsuya KobayashiHenry M Kronenberg
Apr 15, 2008·Archives of Biochemistry and Biophysics·Koichi Matsuo, Naoko Irie
Aug 1, 2008·Nature·Daehyun BaekDavid P Bartel
Aug 1, 2008·Nature·Matthias SelbachNikolaus Rajewsky
Oct 29, 2008·Genome Research·Robin C FriedmanDavid P Bartel
Dec 9, 2008·The Journal of Biological Chemistry·Toshifumi Sugatani, Keith A Hruska
Feb 18, 2009·Journal of Cellular and Molecular Medicine·Xinjun HeJohn H Postlethwait
Feb 24, 2009·Orphanet Journal of Rare Diseases·Zornitza Stark, Ravi Savarirayan
Apr 22, 2009·The Journal of Immunology : Official Journal of the American Association of Immunologists·Jennifer R KieselRajeev Aurora
Sep 22, 2010·Journal of Cellular Physiology·Francesco GrassiGina Lisignoli
Jan 22, 2011·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Lynda F Bonewald
Sep 13, 2011·Nature Medicine·Jinhu XiongCharles A O'Brien
Feb 1, 2012·Nature Reviews. Endocrinology·Jane B LianYing Zhang
May 1, 2012·The Journal of Biological Chemistry·Ying ZhangGary S Stein
Aug 28, 2012·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Sundeep Khosla
Nov 2, 2012·The Journal of Clinical Investigation·Julia F CharlesMary C Nakamura
Dec 12, 2012·Nature Medicine·Xiaogang WangYingxian Li
Dec 15, 2012·Journal of Cellular Biochemistry·Toshifumi Sugatani, Keith A Hruska
May 29, 2013·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Elizabeth ShaneMichael P Whyte
Jul 5, 2013·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Maria Almeida, Charles A O'Brien
Jul 11, 2013·Calcified Tissue International·Cristina Panaroni, Joy Y Wu
Jul 23, 2013·Bone·Youngkyun LeeHong-Hee Kim
Sep 6, 2013·Arthritis Research & Therapy·Fumitaka MizoguchiHitoshi Kohsaka
Sep 10, 2013·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Toshio FumotoKyoji Ikeda

❮ Previous
Next ❯

Citations

May 19, 2021·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·John GarciaAnne M Delany

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Frontiers in Bioscience (Landmark Edition)
Caixia PiBo Gao
Cellular and Molecular Life Sciences : CMLS
Garyfallia PapaioannouTatsuya Kobayashi
Biochemical and Biophysical Research Communications
Shiwu DongFei Kang
© 2021 Meta ULC. All rights reserved