miRNAs Regulation and Its Role as Biomarkers in Endometriosis

International Journal of Molecular Sciences
Josep Marí-AlexandreJuan Sandoval

Abstract

MicroRNAs (miRNAs) are small non-coding RNAs (18-22 nt) that function as modulators of gene expression. Since their discovery in 1993 in C. elegans, our knowledge about their biogenesis, function, and mechanism of action has increased enormously, especially in recent years, with the development of deep-sequencing technologies. New biogenesis pathways and sources of miRNAs are changing our concept about these molecules. The study of the miRNA contribution to pathological states is a field of great interest in research. Different groups have reported the implication of miRNAs in pathologies such as cancer, diabetes, cardiovascular, and gynecological diseases. It is also well-known that miRNAs are present in biofluids (plasma, serum, urine, semen, and menstrual blood) and have been proposed as ideal candidates as disease biomarkers. The goal of this review is to highlight the current knowledge in the field of miRNAs with a special emphasis to their role in endometriosis and the newest investigations addressing the use of miRNAs as biomarkers for this gynecological disease.

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Citations

Nov 16, 2019·Journal of Basic and Clinical Physiology and Pharmacology·Wei Zien GanRhun Yian Koh
Apr 18, 2020·The Journal of International Medical Research·Licong ShenYi Zhang
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Nov 17, 2019·International Journal of Molecular Sciences·Josep Marí-AlexandreJuan Gilabert-Estellés
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Feb 19, 2021·Journal of Gynecology Obstetrics and Human Reproduction·Sema MisirYüksel Aliyazicioglu
Mar 20, 2021·Biology of Reproduction·Abdelrahman AlAshqarMostafa A Borahay
May 7, 2021·Journal of Gynecology Obstetrics and Human Reproduction·Mohummad Hasan Raza RajaRehana Rehman
May 27, 2021·Clinical Epigenetics·Alejandra Monserrat Retis-ResendizEdgar Ricardo Vázquez-Martínez
Aug 8, 2021·International Journal of Molecular Sciences·Bárbara A Mc CormackJuan Gilabert-Estellés

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Methods Mentioned

BETA
RNAseq
PCR
biopsies

Software Mentioned

MIMAT

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