miRNAs reshape immunity and inflammatory responses in bacterial infection.

Signal Transduction and Targeted Therapy
Xikun ZhouMin Wu

Abstract

Pathogenic bacteria cause various infections worldwide, especially in immunocompromised and other susceptible individuals, and are also associated with high infant mortality rates in developing countries. MicroRNAs (miRNAs), small non-coding RNAs with evolutionarily conserved sequences, are expressed in various tissues and cells that play key part in various physiological and pathologic processes. Increasing evidence implies roles for miRNAs in bacterial infectious diseases by modulating inflammatory responses, cell penetration, tissue remodeling, and innate and adaptive immunity. This review highlights some recent intriguing findings, ranging from the correlation between aberrant expression of miRNAs with bacterial infection progression to their profound impact on host immune responses. Harnessing of dysregulated miRNAs in bacterial infection may be an approach to improving the diagnosis, prevention and therapy of infectious diseases.

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Citations

Jan 22, 2020·Journal of Receptor and Signal Transduction Research·Yonglan ZhangWei Wang
Jan 16, 2020·Journal of Clinical Medicine·Barbara StypinskaAgnieszka Paradowska-Gorycka
Mar 20, 2020·Pathogens·Abualgasim Elgaili AbdallaMohammed Alsadig Mousa
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Jul 17, 2020·MSphere·Charles Solomon Akino MercyKalimuthusamy Natarajaseenivasan
Oct 30, 2019·Journal of Receptor and Signal Transduction Research·Xinyu Song, Tianchang Li
May 1, 2020·Journal of Inflammation·Gaohai ShaoZhao Yang
Jan 15, 2020·Signal Transduction and Targeted Therapy·Juanjuan KangJian Huang
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Aug 2, 2021·Molecular Aspects of Medicine·Manish PandeyGeetanjali Chawla
Aug 12, 2021·Journal of Cellular Physiology·Prakash DharmalingamRajarajan A Thandavarayan
Feb 21, 2019·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Yuan YangXiaoguang Zhou

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Methods Mentioned

BETA
GTPase
GTPases
nuclear
antisense oligonucleotide

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