miRNPs: a novel class of ribonucleoproteins containing numerous microRNAs

Genes & Development
Zissimos MourelatosGideon Dreyfuss

Abstract

Gemin3 is a DEAD-box RNA helicase that binds to the Survival of Motor Neurons (SMN) protein and is a component of the SMN complex, which also comprises SMN, Gemin2, Gemin4, Gemin5, and Gemin6. Reduction in SMN protein results in Spinal muscular atrophy (SMA), a common neurodegenerative disease. The SMN complex has critical functions in the assembly/restructuring of diverse ribonucleoprotein (RNP) complexes. Here we report that Gemin3 and Gemin4 are also in a separate complex that contains eIF2C2, a member of the Argonaute protein family. This novel complex is a large approximately 15S RNP that contains numerous microRNAs (miRNAs). We describe 40 miRNAs, a few of which are identical to recently described human miRNAs, a class of small endogenous RNAs. The genomic sequences predict that miRNAs are likely to be derived from larger precursors that have the capacity to form stem-loop structures.

References

Oct 23, 1997·Current Opinion in Neurology·J Melki
Mar 22, 2000·The Journal of Cell Biology·B CharrouxG Dreyfuss
Apr 5, 2000·Nature·C CatalanottoC Cogoni
Jun 24, 2000·Nature·A Pandey, M Mann
Oct 4, 2000·Proceedings of the National Academy of Sciences of the United States of America·M FagardH Vaucheret
Jan 10, 2001·The Journal of Cell Biology·L PellizzoniG Dreyfuss
Feb 7, 2001·Genes & Development·S M ElbashirT Tuschl
Mar 10, 2001·Genes & Development·P A Sharp
Jun 26, 2001·Science·V Vance, H Vaucheret
Sep 28, 2001·The EMBO Journal·Z MourelatosG Dreyfuss
Oct 27, 2001·Science·M Lagos-QuintanaT Tuschl
Oct 27, 2001·Science·R C Lee, V Ambros
Nov 21, 2001·The Journal of Biological Chemistry·Amelie K GubitzGideon Dreyfuss

❮ Previous
Next ❯

Citations

May 25, 2011·Cellular and Molecular Life Sciences : CMLS·Julia Starega-RoslanWlodzimierz J Krzyzosiak
Sep 24, 2005·Mammalian Genome : Official Journal of the International Mammalian Genome Society·Milena SaweraMerete Fredholm
Mar 7, 2006·Mammalian Genome : Official Journal of the International Mammalian Genome Society·Cinzia SevignaniCarlo M Croce
Jul 19, 2008·Mammalian Genome : Official Journal of the International Mammalian Genome Society·Simona RossiGeorge A Calin
Jul 30, 2011·Histochemistry and Cell Biology·Barbara Ginter-MatuszewskaJadwiga Jaruzelska
Mar 1, 2012·Histochemistry and Cell Biology·Stefan Hübner, Athina Efthymiadis
May 25, 2012·Cell and Tissue Research·Mahboob Ul Hussain
Oct 6, 2009·Functional & Integrative Genomics·Sadegh Azimzadeh Jamalkandi, Ali Masoudi-Nejad
Mar 2, 2010·Journal of Clinical Immunology·Adrian ListonLi-Fan Lu
Oct 18, 2005·Journal of Biomedical Science·Shao-Yao Ying, Shi-Lung Lin
Apr 18, 2009·Journal of Gastrointestinal Surgery : Official Journal of the Society for Surgery of the Alimentary Tract·Imran BhattiMichael Larvin
Oct 27, 2010·Irish Journal of Medical Science·B ZhouD Luo
May 5, 2011·Molecular Neurobiology·Claire Perruisseau-CarrierColin P McGuckin
Jan 20, 2010·Virologica Sinica·Zhi-Qiang BaiShou-Jiang Gao
Jun 19, 2010·Journal of Cardiovascular Translational Research·Chang Won ParkClifford J Steer
Jan 31, 2013·Archives of Pharmacal Research·Seung-Yoon ParkWan Lee
Jun 16, 2004·Current Opinion in Cell Biology·Kenji Nakahara, Richard W Carthew
Feb 14, 2004·Clinical Immunology : the Official Journal of the Clinical Immunology Society·Laura M StintonMarvin J Fritzler
Jan 21, 2004·Current Opinion in Plant Biology·Andrea SteimerUeli Grossniklaus
Mar 9, 2004·Current Opinion in Plant Biology·Allison C Mallory, Hervé Vaucheret
Jun 1, 2005·Current Opinion in Structural Biology·Witold FilipowiczRamesh S Pillai
Jan 19, 2008·Theory in Biosciences = Theorie in Den Biowissenschaften·Athanasius F BompfünewererChristina Witwer
Oct 16, 2003·Trends in Biochemical Sciences·Peter NelsonZissimos Mourelatos
Jan 16, 2004·Trends in Pharmacological Sciences·Mouldy Sioud
Apr 8, 2004·Virus Research·Bryan R Cullen
Oct 22, 2003·Molecular Genetics and Metabolism·Jerry C ChengKathleen M Sakamoto
Jun 19, 2003·Developmental Biology·Arash BashirullahCarl S Thummel
Oct 22, 2003·Cell·Dianne S SchwarzPhillip D Zamore
Mar 24, 2004·Cell·Yukihide TomariPhillip D Zamore
Dec 21, 2002·Trends in Genetics : TIG·Heriberto Cerutti
Aug 12, 2003·Gene·Edward SilvermanRen-Jang Lin
Aug 9, 2003·Genomics·Takashi SasakiNobuyoshi Shimizu
Jul 31, 2003·Current Opinion in Genetics & Development·Christine Hunter, R Scott Poethig
May 3, 2003·Current Biology : CB·Zhixin XieJames C Carrington
Apr 26, 2003·Trends in Biochemical Sciences·Ahmet M Denli, Gregory J Hannon
Oct 18, 2003·Seminars in Cancer Biology·Michael T McManus
Dec 10, 2002·Current Opinion in Chemical Biology·Alexander HüttenhoferJean Pierre Bachellerie
Aug 28, 2003·Current Opinion in Chemical Biology·Xi-Song KeChih-Chuan Liang
Aug 16, 2008·Expert Reviews in Molecular Medicine·Erica Hennessy, Lorraine O'Driscoll
Jul 12, 2002·Nature·Carina Dennis
Jul 12, 2002·Nature·Gregory J Hannon
Oct 15, 2013·Acta Pharmacologica Sinica·Zheng-ming WangYaguang Xi
Sep 17, 2004·Nature·Gunter Meister, Thomas Tuschl
Nov 13, 2012·Nature Cell Biology·Derrick GibbingsOlivier Voinnet
Mar 23, 2005·Nature Methods·Peter T NelsonZissimos Mourelatos

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cajal Bodies & Gems

Cajal bodies or coiled bodies are dense foci of coilin protein. Gemini of Cajal bodies, or gems, are microscopically similar to Cajal bodies. It is believed that Cajal bodies play important roles in RNA processing while gems assist the Cajal bodies. Find the latest research on Cajal bodies and gems here.