Mirogabalin and emerging therapies for diabetic neuropathy

Journal of Pain Research
Saad JavedRayaz A Malik

Abstract

There are currently no approved disease-modifying therapies for diabetic neuropathy, and there are only 3 US Food and Drug Administration-approved therapies (pregabalin, duloxetine, and tapentadol) for painful diabetic neuropathy. They each have moderate efficacy with adverse effects limiting optimal dose titration. There is a considerable need for new therapies for the management of painful diabetic neuropathy. We reviewed the potential role of mirogabalin, which like gabapentin and pregabalin modulates the alpha-2/delta-1 subunit of the voltage-gated calcium channel, allowing the influx of calcium and release of neurotransmitters at the synaptic cleft in the central nervous system and spinal cord. It has shown efficacy and good tolerability in a Phase II study in diabetic painful neuropathy and based on the results of two Phase III clinical trials in diabetic painful neuropathy and post-herpetic neuralgia, Daiichi Sankyo submitted a marketing application for neuropathic pain in Japan in February 2018. We have also reviewed potential new therapies, currently in Phase II clinical trials that may modify disease and/or relieve neuropathic pain through novel modes of action.

Citations

Feb 11, 2020·Drugs·Uazman AlamSolomon Tesfaye
Apr 3, 2020·The Korean Journal of Pain·Kyung-Hoon KimBilly Huh
Sep 1, 2020·Expert Opinion on Pharmacotherapy·Shazli AzmiRayaz A Malik
Apr 23, 2019·Pain·Nadine Attal, Didier Bouhassira
Feb 21, 2019·Therapeutic Advances in Endocrinology and Metabolism·Shazli AzmiRayaz A Malik
May 28, 2020·Journal of Orthopaedic Surgery and Research·Tomoko TetsunagaToshifumi Ozaki
Apr 27, 2020·Toxicology in Vitro : an International Journal Published in Association with BIBRA·Mohammad ShokrzadehNasrin Ghassemi-Barghi
Jan 1, 2021·The Korean Journal of Pain·Jae-Yeon KimKyung-Hoon Kim
Jan 12, 2021·Expert Opinion on Investigational Drugs·Marc S Rendell
May 30, 2021·Nature Reviews. Endocrinology·Gordon SloanSolomon Tesfaye

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Methods Mentioned

BETA
confocal microscopy

Software Mentioned

COMBO

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