Mirtazapine abolishes hyperthermia in an animal model of serotonin syndrome

Neuroscience Letters
Katsutoshi ShiodaSatoshi Kato

Abstract

Serotonin (5-HT) syndrome is a potentially fatal condition associated with various combinations of serotonergic drugs. Hyperthermia is the most serious symptom of this syndrome. Hyperthermia in 5-HT syndrome is reportedly the result of activation of 5-HT(2A) receptors. Mirtazapine is a novel antidepressant and a potent 5-HT(2) receptor antagonistic. Although mirtazapine has been reported to cause 5-HT syndrome, the pharmacological profile of mirtazapine suggests that it improves hyperthermia in 5-HT syndrome. In the present study, we evaluated whether mirtazapine attenuates hyperthermia in a rat model of 5-HT syndrome. This model was induced by administration of tranylcypromine, a nonselective monoamine oxidase inhibitor, and fluoxetine, a selective serotonin reuptake inhibitor. Upon injection of these two drugs, the rectal temperature of the rats increased to over 40 degrees C. Pre- and post-administration of mirtazapine abolishes hyperthermia in this model of 5-HT syndrome. Post-administration of ritanserin, a 5-HT(2A) receptor antagonist, completely inhibited hyperthermia and pre-administration of WAY100635, a 5-HT(1A) receptor antagonist, significantly attenuated the ability of mirtazapine to abolish hyperthermia. The resul...Continue Reading

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Citations

Dec 17, 2011·CNS Drugs·Edoardo SpinaFilippo Caraci
Sep 6, 2013·Behavioural Brain Research·Robert HaberzettlMeredith A Fox
Mar 15, 2013·Neurochemistry International·Adam Michael StewartAllan V Kalueff
Jun 29, 2017·European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology·Sven UlrichMazda Adli
Jul 1, 2014·Journal of Clinical Psychopharmacology·Nicolas AnsermotChin B Eap
Sep 12, 2017·Forensic Toxicology·Genri KawaharaYukiko K Hayashi
Aug 10, 2021·Journal of Clinical Psychopharmacology·Erhan Kavakbasi, Bernhard T Baune

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