Mirtazapine for patients with alcohol dependence and comorbid depressive disorders: a multicentre, open label study

Progress in Neuro-psychopharmacology & Biological Psychiatry
Su-Jung YoonChung Tai Lee

Abstract

Major depressive disorder and alcohol dependence are common and serious mental illnesses. There is a great interest in discovering useful treatments for both mood symptoms and alcohol abuse in those patients with depressive disorders and comorbid alcohol dependence. The primary purpose of this study was to evaluate the effectiveness and tolerability of mirtazapine for the treatment of patients with alcohol dependence comorbid with a depressive disorder in an open label, naturalistic multicentre treatment setting. The 17-item Hamilton Depression Rating Scale (HDRS), the Hamilton Anxiety Rating Scale (HARS) and the Clinical Global Impression-Severity (CGI-S) scale were measured at baseline and at weeks 4 and 8 for the assessment of treatment effectiveness. Alcohol craving was measured using the Obsessive Compulsive Drinking Scale (OCDS) and the Visual Analog Scale for Craving (VAS). This study showed a statistically significant reduction of the scores on the HDRS (13.9+/-7.3, p<0.0001), HARS (10.8+/-7.2, p<0.0001) and the CGI-S (1.7+/-1.0, p<0.0001) from baseline to the endpoint (week 8). The OCDS and VAS scores were also decreased significantly by 42.3% and 53.2% (9.0+/-10.0, p<0.0001; 2.5+/-2.4, p<0.0001, respectively). The num...Continue Reading

References

Jan 1, 1991·Journal of Studies on Alcohol·S A BrownM A Schuckit
Sep 1, 1988·Journal of Studies on Alcohol·S A Brown, M A Schuckit
Jan 1, 1995·The American Journal of Psychiatry·S A BrownM R Irwin
Sep 1, 1994·Biological Psychiatry·D LeMarquandC Benkelfat
Mar 1, 1996·Archives of General Psychiatry·P J McGrathF M Quitkin
Aug 1, 1996·Journal of Consulting and Clinical Psychology·M A Schuckit
Dec 1, 1995·International Clinical Psychopharmacology·T de Boer
Dec 1, 1995·International Clinical Psychopharmacology·S Kasper
Dec 1, 1995·International Clinical Psychopharmacology·S A Montgomery
Apr 6, 1999·Addictive Behaviors·J R CorneliusJ M Perel
Apr 30, 1999·International Clinical Psychopharmacology·K M ConnorE Ahearn
May 27, 1999·Alcohol and Alcoholism : International Journal of the Medical Council on Alcoholism·A S PotgieterP Geerlings
Jan 31, 2002·The Journal of Clinical Psychiatry·M E ThaseUNKNOWN Relapse Prevention Study Group
Nov 5, 2002·Human Psychopharmacology·Won-Myong BahkKwang-Soo Kim
Jan 1, 1959·The British Journal of Medical Psychology·M HAMILTON
Feb 1, 1960·Journal of Neurology, Neurosurgery, and Psychiatry·M HAMILTON
Nov 19, 2003·Journal of Clinical Psychopharmacology·Darlene H MoakRamon Durazo-Arvizu
Apr 27, 2004·Journal of Psychopharmacology·J LiappasG Christodoulou
Apr 29, 2004·Alcoholism, Clinical and Experimental Research·William J McBrideBankole A Johnson
Jul 2, 2004·The American Journal of Psychiatry·Rosa M CrumDaniel E Ford
Nov 3, 2004·Alcohol and Alcoholism : International Journal of the Medical Council on Alcoholism·Dai-Jin KimJaeseung Jeong
Dec 22, 2004·Progress in Neuro-psychopharmacology & Biological Psychiatry·John LiappasAndreas Rabavilas
Apr 9, 2005·The Journal of Clinical Psychiatry·David N Crockford, William D White

❮ Previous
Next ❯

Citations

Jun 4, 2010·Psychopharmacology·Margaret HaneyRichard W Foltin
Mar 25, 2011·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Emmanuelle Simon O'BrienMickaël Naassila
Dec 12, 2012·Journal of Dual Diagnosis·Jack R CorneliusDennis Daley
Feb 22, 2008·Psychiatry and Clinical Neurosciences·Sung-Wan KimJin-Sang Yoon
Nov 26, 2010·Biological Psychiatry·Steven M Graves, T Celeste Napier
Oct 31, 2015·Progress in Neuro-psychopharmacology & Biological Psychiatry·Laurence LalanneElisabeth Bacon
Jan 10, 2012·The American Journal of Drug and Alcohol Abuse·Maryam AfsharDomenic A Ciraulo
May 25, 2016·Progress in Neuro-psychopharmacology & Biological Psychiatry·Nathan A HoltzT Celeste Napier
Sep 6, 2008·Progress in Brain Research·Marcy J Bubar, Kathryn A Cunningham
May 26, 2012·Journal of Psychopharmacology·A R Lingford-HughesUNKNOWN British Association for Psychopharmacology, Expert Reviewers Group
Jan 4, 2019·Expert Opinion on Pharmacotherapy·Thomas Hillemacher, Helge Frieling
Jan 5, 2020·Expert Opinion on Pharmacotherapy·Pierre A GeoffroyBenjamin Rolland

❮ Previous
Next ❯

Related Concepts

Related Feeds

Antipsychotic Drugs

Antipsychotic drugs are a class of medication primarily used to manage psychosis (including delusions, hallucinations, paranoia or disordered thought), principally in schizophrenia and bipolar disorder. Discover the latest research on antipsychotic drugs here