Miscarriage history association with euploid embryo transfer outcomes

Reproductive Biomedicine Online
Ange WangLynn M Westphal

Abstract

Is a history of miscarriage (including recurrent pregnancy loss) associated with euploid cryopreserved embryo transfer outcomes? Retrospective cohort study from 2014 to 2018 of patients at an academic medical centre, undergoing their first cycle of IVF with 24-chromosome Day 5/6 preimplantation genetic testing for aneuploidies (IVF-PGT-A). Multivariate logistic regression was used to investigate the relationship between history of miscarriage and euploid single cryopreserved embryo transfer outcomes (ongoing pregnancy, miscarriage), adjusting for an extensive list of patient and cycle confounders. In the study cohort of 283 patients, the overall unadjusted positive beta human chorionic gonadotrophin (bHCG) rate was 70.0%, ongoing pregnancy rate was 52.3%, and the total pregnancy loss (biochemical and clinical pregnancy loss) rate per positive bHCG cycle was 24.7%. While 35.3% of patients had a history of at least one previous miscarriage, 14.5% of patients had a history of recurrent pregnancy loss (RPL). For patients with a history of miscarriage, it was found that the adjusted odds ratios (OR) and 95% confidence intervals (CI) for positive bHCG were 1.30 (0.51-3.27), for ongoing pregnancy were 0.88 (0.38-2.03) and for total pr...Continue Reading

Citations

Jul 25, 2019·Archives of Gynecology and Obstetrics·Ange WangLynn Westphal
Apr 10, 2021·Reproductive Biomedicine Online·Fazilet Kübra BoynukalinMustafa Bahceci

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