Miscibility analysis of particulate solid dispersions prepared by electrospray deposition

International Journal of Pharmaceutics
Kohsaku Kawakami

Abstract

Physical characteristics of solid dispersions were investigated using carbamazepine (CBZ) and prednisolone (PDN) as model drugs, and poly(vinyl pyrrolidone) and Eudragit as polymeric excipients. Electrospray method provided particulate formulations, of which the particle size was typically in the order of micrometers, when the polymer concentration of the solution used for the preparation was below 2% (w/v). Decrease of the solution concentration and flow rate resulted in a decrease in the particle diameter, as theoretically expected. Also, the particle size could be reduced to 400 nm by increasing the conductivity of the solution by the addition of salts. When poly(vinyl pyrrolidone) K90 was used as an excipient, CBZ was homogeneously loaded up to ca. 40%, and if a greater amount was added, the excess CBZ was separated as a pure crystalline phase. PDN was homogeneously loaded up to ca. 60%. However, in contrast to CBZ, excess PDN maintained the amorphous state, even when a greater amount was added. The separated excess PDN phase was crystallized in the heating process during thermal analysis. In addition to the thermodynamic factor, there seems to be a dynamic factor to separate drug phase from the excipient phase, depending o...Continue Reading

References

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Oct 10, 2006·Physical Review Letters·Tohru OkuzonoMasao Doi
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Aug 5, 2009·Advanced Drug Delivery Reviews·Syandan ChakrabortyKam W Leong
Feb 23, 2010·International Journal of Pharmaceutics·Kohsaku KawakamiKatsuhide Terada
Jul 14, 2010·Journal of Pharmaceutical Sciences·Jared A BairdLynne S Taylor
Jul 20, 2010·International Journal of Pharmaceutics·Shaoling Zhang, Kohsaku Kawakami
Mar 15, 2011·Molecular Pharmaceutics·Shaoling ZhangShinji Sakuma

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Citations

Nov 20, 2012·Journal of Pharmaceutical Sciences·Kohsaku KawakamiKatsuhide Terada
Jul 8, 2015·Therapeutic Delivery·Adeola O Adebisi, Barbara R Conway
Sep 24, 2013·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·Chau Le-Ngoc VoBeom-Jin Lee
Jun 12, 2016·Journal of Pharmaceutical Sciences·Duong Nhat NguyenGuy Van den Mooter
Mar 4, 2017·Materials Science & Engineering. C, Materials for Biological Applications·Hangyi LuQufu Wei
May 3, 2014·Chemical & Pharmaceutical Bulletin·Usharani NagarajanBalachandran Unni Nair
May 28, 2021·Molecular Pharmaceutics·Samarth D ThakoreArvind K Bansal
May 24, 2019·The Journal of Physical Chemistry. B·Kohsaku Kawakami

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