PMID: 8971069Dec 25, 1996Paper

Misdiagnosis of multidrug-resistant tuberculosis possibly due to laboratory-related errors

JAMA : the Journal of the American Medical Association
A T NittaR J Kilman

Abstract

To describe 9 cases where a misdiagnosis of multidrug-resistant tuberculosis (MDR TB) was made, possibly due to laboratory-related errors. Case series. Public and private hospitals, outpatient clinics, and mycobacteriology laboratories serving those institutions in Los Angeles County, Calif. Consecutive sample of 70 patients diagnosed with MDR TB who were identified between August 1993 and August 1994 by the Multidrug-Resistant Unit within TB Control in Los Angeles County. Detection of laboratory-related diagnostic errors. Pulmonary MDR TB was misdiagnosed in 9 (13%) of 70 patients. Reasons why the diagnoses appeared to be erroneous are as follows: growth of MDR TB from an old tuberculous lesion in a patient who was never treated for TB and whose diagnosis predated anti-TB drugs (1 case), documented contamination with Mycobacterium avium complex (1 case), suspected cross-contamination (1 case), suspected specimen mislabeling (1 case), successful treatment using drugs to which the isolate was reportedly resistant (4 cases), discrepant susceptibility test results on additional sputum specimens submitted by the patient (2 cases), and no clinical evidence of TB (3 cases). These cases emphasize the diagnostic errors that can occur i...Continue Reading

Citations

Oct 1, 2006·Medical Journal, Armed Forces India·K ChandV Vardhan
May 9, 2006·Diagnostic Microbiology and Infectious Disease·David A J MooreJon S Friedland
Oct 29, 2002·Infection Control and Hospital Epidemiology : the Official Journal of the Society of Hospital Epidemiologists of America·Gonzalo BearmanGianna Zuccotti
Feb 2, 2018·Clinical Microbiology Reviews·Betty A ForbesMichael L Wilson
Jan 17, 2008·Respirology : Official Journal of the Asian Pacific Society of Respirology·Wing Wai Yew, Chi Chiu Leung
Mar 19, 2002·American Journal of Respiratory and Critical Care Medicine·Annette T NittaMuriel L De Koning

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