Misdiagnosis of vertebral fractures on local radiographic readings of the multicentre POINT (Prevalence of Osteoporosis in INTernal medicine) study

Bone
D DiacintiResearch Department of FADOI

Abstract

Osteoporotic vertebral fractures (VFs) are often misdiagnosed because asymptomatic and occurring in the absence of specific trauma. Further, diagnostic assessment of VFs may be suboptimal. To assess the misdiagnosis of vertebral fractures on local radiographic readings in the cohort of patients enrolled in the POINT study. We enrolled hospitalised patients, admitted for any cause to the Internal Medicine Units of 37 hospitals participating to the cross-sectional previously published POINT study. The assessment of VFs was performed both by local radiologists and by two expert skeletal radiologists, by using semiquantitative method (SQ). To better evaluate mild vertebral deformities, the two central radiologists also used the algorithm-based qualitative assessment (ABQ). The radiographs of 661 patients (401 females; mean age 75.8±8.0) were evaluated. The inter-reader percent agreement between two central expert radiologists per-vertebra assessment was excellent (99.78%; k=0.984; 95% CI, 0.977-0.991). Central reading identified 318/661 (48.1%) patients with at least one VF. Local and central readings agreed in 502/661 (75.9%) patients, resulting in a fair reproducibility (k=0.52; 95% confidence interval 0.44-0.59). Diagnostic perf...Continue Reading

Citations

Jan 23, 2019·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·Y X J WángP C Leung
Jun 17, 2020·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Lisa JohanssonMattias Lorentzon
Dec 8, 2019·Revista clínica española·A Capdevila-ReniuA López-Soto
Feb 11, 2021·The Journal of Clinical Endocrinology and Metabolism·Cristiana CiprianiDaniele Diacinti
May 18, 2021·Revista Clínica Espanõla·A Capdevila-ReniuA López-Soto

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