Misexpression of Fgf-4 in the chick limb inhibits myogenesis by down-regulating Frek expression

Developmental Biology
F Edom-VovardDelphine Duprez

Abstract

Skeletal muscle development involves an initial period of myoblast replication followed by a phase in which some myoblasts continue to proliferate while others undergo terminal differentiation. The latter process involves the permanent cessation of DNA synthesis, activation of muscle-specific gene expression, and fusion of single cells to generate multinucleated muscle fibres. The in vivo signals regulating the progression through all these steps remain unknown. Fibroblast growth factors (Fgfs) and Fgf receptors comprise a large family whose members have been shown to play multiple roles in the development of skeletal muscle in vitro. Exogenously applied Fgfs are able to stimulate proliferation and suppress myogenic differentiation in cell culture. We sought to determine the role played by Fgf-4 during limb myogenesis in vivo. Fgf-4 transcripts are located at both extremities of myotubes whereas the mRNAs of one of the Fgf receptors, Frek, are detected in mononucleated proliferating myoblasts surrounding the multinucleated fibres. Overexpression of mouse Fgf-4 (mFgf-4) using a replication-competent retrovirus, RCAS, leads to a down-regulation of muscle markers followed by an inhibition of terminal differentiation in limb muscle...Continue Reading

References

Oct 1, 1977·Developmental Biology·P B AhrensR S Reiter
Mar 30, 1977·Anatomy and Embryology·B ChristM Jacob
Aug 1, 1975·The Journal of Cell Biology·D Gospodarowicz, J S Moran
Aug 1, 1990·Molecular and Cellular Biology·K E YutzeyS F Konieczny
Nov 1, 1990·Experimental Cell Research·J N Schofield, L Wolpert
Jan 1, 1990·Anatomy and Embryology·C Schramm, M Solursh
Jan 23, 1987·Science·J Folkman, M Klagsbrun
Jan 1, 1987·Nouvelle Revue Française D'hématologie·A Camez, G Tobelem
May 1, 1985·The Journal of Cell Biology·B LathropL Glaser
Jul 1, 1969·The Journal of Cell Biology·A M Kelly, S I Zacks
May 1, 1995·Anatomy and Embryology·B Christ, C P Ordahl
Jan 13, 1995·Science·B FeldmanM Goldfarb
Mar 1, 1993·In Vitro Cellular & Developmental Biology : Journal of the Tissue Culture Association·J C Fox, J L Swain
Jan 1, 1996·The Journal of Cell Biology·S YoshidaY Nabeshima
Oct 1, 1995·Developmental Dynamics : an Official Publication of the American Association of Anatomists·M Zhang, I S McLennan
Jul 1, 1996·Developmental Dynamics : an Official Publication of the American Association of Anatomists·C GrotheB Christ
Sep 1, 1997·Developmental Dynamics : an Official Publication of the American Association of Anatomists·T A WilkeJ M Richman
Jun 17, 1998·Genes & Development·G R Martin

❮ Previous
Next ❯

Citations

Jan 1, 2003·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·Margaret Buckingham
Apr 25, 2003·Developmental Biology·Nicolas HollevilleAnne Hélène Monsoro-Burq
Jul 19, 2008·Nature Reviews. Genetics·Robert J Bryson-Richardson, Peter D Currie
Feb 18, 2003·Journal of Anatomy·Philippa H Francis-WestKelly Anakwe
Feb 18, 2003·Journal of Anatomy·Margaret BuckinghamFrédéric Relaix
Jan 18, 2007·Development, Growth & Differentiation·Haruki Ochi, Monte Westerfield
Apr 12, 2007·BMC Musculoskeletal Disorders·John EashKevin Hannon
May 1, 2007·Regenerative Medicine·Andrea Hoffmann, Gerhard Gross
Mar 16, 2005·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Akira SatohKoji Tamura
Apr 23, 2009·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Sophie Eloy-TrinquetDelphine Duprez
Apr 22, 2011·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Hui WangDelphine Duprez
Jun 21, 2011·Developmental Biology·Yvette Bren-MattisonBradley B Olwin
Jun 28, 2002·Developmental Biology·Frédérique Edom-VovardDelphine Duprez
Oct 2, 2001·Mechanisms of Development·F Edom-VovardD Duprez
Mar 3, 2004·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Frédérique Edom-Vovard, Delphine Duprez
Dec 10, 2017·Scientific Reports·Sonya NassariClaire Fournier-Thibault
May 23, 2018·Journal of Developmental Biology·Chih-Ning Chang, Chrissa Kioussi
Sep 28, 2005·Birth Defects Research. Part C, Embryo Today : Reviews·Samuel Tozer, Delphine Duprez
Jun 18, 2003·Development·Kelly AnakwePhilippa Francis-West
Jun 24, 2021·Nature Communications·Wesal YaseenPeleg Hasson
Jun 24, 2021·Nature Communications·Joana Esteves de LimaDelphine Duprez
Oct 2, 2021·Cell Regeneration·Joana Esteves de Lima, Frédéric Relaix

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.