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Misfolded proteins as a therapeutic target in Alzheimer's disease

Advances in Protein Chemistry and Structural Biology

Jan 14, 2020

S Imindu Liyanage, Donald F Weaver

Abstract

For decades, Alzheimer's Disease (AD) was defined as a disorder of protein misfolding and aggregation. In particular, the extracellular peptide fragment: amyloid-β (Aβ), and the intracellular microtubule-associated protein: tau, were thought to initiate a neurodegenerative cascade which...read more

Mentioned in this Paper

Extracellular
Pathologic Processes
Amyloid beta-Peptides
Memory
Explanation of Plan: Medication
Cell Cycle Arrest
Protein Aggregation, Pathological
Peptide Fragments
Neurodegenerative Disorders
Executive Function
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Paper Details
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Misfolded proteins as a therapeutic target in Alzheimer's disease

Advances in Protein Chemistry and Structural Biology

Jan 14, 2020

S Imindu Liyanage, Donald F Weaver

PMID: 31928732

DOI: 10.1016/bs.apcsb.2019.08.003

Abstract

For decades, Alzheimer's Disease (AD) was defined as a disorder of protein misfolding and aggregation. In particular, the extracellular peptide fragment: amyloid-β (Aβ), and the intracellular microtubule-associated protein: tau, were thought to initiate a neurodegenerative cascade which...read more

Mentioned in this Paper

Extracellular
Pathologic Processes
Amyloid beta-Peptides
Memory
Explanation of Plan: Medication
Cell Cycle Arrest
Protein Aggregation, Pathological
Peptide Fragments
Neurodegenerative Disorders
Executive Function
1
1

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