Misfolded proteins: from little villains to little helpers in the fight against cancer

Frontiers in Oncology
Ansgar Brüning, Julia Jückstock

Abstract

The application of cytostatic drugs targeting the high proliferation rates of cancer cells is currently the most commonly used treatment option in cancer chemotherapy. However, severe side effects and resistance mechanisms may occur as a result of such treatment, possibly limiting the therapeutic efficacy of these agents. In recent years, several therapeutic strategies have been developed that aim at targeting not the genomic integrity and replication machinery of cancer cells but instead their protein homeostasis. During malignant transformation, the cancer cell proteome develops vast aberrations in the expression of mutated proteins, oncoproteins, drug- and apoptosis-resistance proteins, etc. A complex network of protein quality-control mechanisms, including chaperoning by heat shock proteins (HSPs), not only is essential for maintaining the extravagant proteomic lifestyle of cancer cells but also represents an ideal cancer-specific target to be tackled. Furthermore, the high rate of protein synthesis and turnover in certain types of cancer cells can be specifically directed by interfering with the proteasomal and autophagosomal protein recycling and degradation machinery, as evidenced by the clinical application of proteasom...Continue Reading

References

Aug 1, 1992·Molecular and Cellular Biology·N HosokawaK Nagata
Jul 20, 1973·Science·C B Anfinsen
Mar 28, 1995·Biochemical and Biophysical Research Communications·N NagaiK Nagata
May 15, 1994·The Biochemical Journal·G Elia, M G Santoro
Dec 21, 2000·Trends in Cell Biology·R R Kopito
May 16, 2002·Traffic·Rafael Garcia-MataElizabeth Sztul
May 25, 2002·Critical Reviews in Biochemistry and Molecular Biology·Chung-Jung TsaiRuth Nussinov
Jul 6, 2002·Critical Reviews in Oncology/hematology·Bert HildebrandtHanno Riess
Jul 31, 2002·The Lancet Oncology·P WustP M Schlag
Aug 6, 2002·The Journal of Biological Chemistry·M Patricia HernándezDavid O Toft
Apr 5, 2003·Proceedings of the National Academy of Sciences of the United States of America·Stephen J HaggartyStuart L Schreiber
Jul 10, 2003·Molecular Membrane Biology·Eileithyia Swanton, Neil J Bulleid
Dec 20, 2003·Nature·Dennis J Selkoe
Apr 23, 2004·Current Opinion in Structural Biology·José Nelson Onuchic, Peter G Wolynes
May 4, 2004·Nature Reviews. Cancer·Julian Adams
Jun 16, 2004·International Journal of Hyperthermia : the Official Journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group·J R Lepock
Mar 17, 2005·Cellular and Molecular Life Sciences : CMLS·M P Mayer, B Bukau
Jun 7, 2005·Proceedings of the National Academy of Sciences of the United States of America·Teru HideshimaKenneth C Anderson
Oct 6, 2005·International Journal of Cancer. Journal International Du Cancer·Henrik LövborgRolf Larsson
Apr 11, 2006·Nuclear Receptor Signaling·Jeffrey J KovacsTso-Pang Yao
Jun 3, 2006·Biological Chemistry·R John Ellis, Allen P Minton
Jul 1, 2006·The EMBO Journal·Cyril BoyaultSaadi Khochbin
Nov 1, 2006·Proceedings of the National Academy of Sciences of the United States of America·George D RoseAmos Maritan
Jul 24, 2007·Pathobiology : Journal of Immunopathology, Molecular and Cellular Biology·A AigelsreiterH Denk
Sep 6, 2007·Genes & Development·Cyril BoyaultSaadi Khochbin
Sep 6, 2007·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Joell J GillsPhillip A Dennis
Dec 1, 2007·Cell Death and Differentiation·A Strasser, H Puthalakath
Jan 25, 2008·International Journal of Hyperthermia : the Official Journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group·Joseph L Roti Roti
Jul 17, 2008·Clinical & Translational Oncology : Official Publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico·O Martínez-IglesiasA Aranda
Sep 16, 2008·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Rolf D Issels
Jan 24, 2009·Proceedings of the National Academy of Sciences of the United States of America·Qiuyan WangYihong Ye
Apr 2, 2009·Expert Opinion on Therapeutic Targets·Luke Whitesell, Susan Lindquist
May 14, 2009·International Journal of Hyperthermia : the Official Journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group·Gabriele Multhoff

❮ Previous
Next ❯

Citations

Dec 24, 2015·International Journal of Molecular Sciences·Yuichi TsuchiyaHiroyasu Nakano
May 29, 2015·The Tohoku Journal of Experimental Medicine·Meral GunaldiElif Eda Tiken
Mar 3, 2020·Frontiers in Chemistry·Maria E GierischNico P Dantuma

❮ Previous
Next ❯

Methods Mentioned

BETA
protein folding
ubiquitination
nuclear translocation
acetylation
glycosylation
xenograft

Related Concepts

Related Feeds

Apoptosis

Apoptosis is a specific process that leads to programmed cell death through the activation of an evolutionary conserved intracellular pathway leading to pathognomic cellular changes distinct from cellular necrosis

B-Cell Lymphoma

B-cell lymphomas include lymphomas that affect B cells. This subtype of cancer accounts for over 80% of non-Hodgkin lymphomas in the US. Here is the latest research.

Apoptosis in Cancer

Apoptosis is an important mechanism in cancer. By evading apoptosis, tumors can continue to grow without regulation and metastasize systemically. Many therapies are evaluating the use of pro-apoptotic activation to eliminate cancer growth. Here is the latest research on apoptosis in cancer.

Blood And Marrow Transplantation

The use of hematopoietic stem cell transplantation or blood and marrow transplantation (bmt) is on the increase worldwide. BMT is used to replace damaged or destroyed bone marrow with healthy bone marrow stem cells. Here is the latest research on bone and marrow transplantation.

© 2022 Meta ULC. All rights reserved