Mismatch repair deficiency as a prognostic factor in mucinous colorectal cancer

Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc
Juliana AndriciAnthony J Gill

Abstract

There is some uncertainty about pathological grading of mucinous colorectal adenocarcinoma, defined as colorectal cancer demonstrating at least 50% mucinous differentiation. Under the WHO 2000 classification mucinous colorectal cancer was considered high grade. However under the current WHO 2010 classification microsatellite unstable/mismatch repair-deficient (MSI/MMRd) mucinous colorectal cancer is considered low grade, whereas microsatellite stable/mismatch repair proficient (MSS/MMRp) tumours are high grade. However there is little empirical evidence for this approach. We therefore compared the long term survival of patients with MSI/MMRd vs MSS/MMRp mucinous colorectal cancer in a large unselected cohort of patients undergoing surgery at our institution from 1998 to 2011. There were 2608 patients in the cohort, of which 264 (10.1%) were mucinous. 95 (36%) of the mucinous tumours were microsatellite unstable. The all-cause 5-year survival of mucinous MSI/MMRd colorectal cancer was similar to that of non-mucinous low-grade colorectal cancer (73 vs 67%, P=0.368), and significantly better than that of both non-mucinous high-grade (73 vs 53%, P<0.001) and mucinous MSS/MMRp colorectal cancer (73 vs 57%, P=0.023). The 5-year survi...Continue Reading

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Citations

Apr 22, 2017·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Charly LiddellJean-François Mosnier
Sep 5, 2018·The American Journal of Surgical Pathology·Melanie JohncillaRhonda K Yantiss
Jan 15, 2019·Expert Review of Molecular Diagnostics·Ian Baine, Pei Hui
Mar 30, 2019·Cancer Communications·Cong LuoWei Wu
Apr 5, 2019·The British Journal of Surgery·I S ReynoldsJ P Burke
Nov 16, 2019·Journal of Surgical Oncology·Ian S ReynoldsJohn P Burke
Dec 20, 2018·BMC Cancer·Vincenza BarresiDaniele F Condorelli
Feb 7, 2020·Clinical Journal of Gastroenterology·Monia Di PreteAugusto Orlandi
Feb 13, 2020·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·David S WilliamsOliver M Sieber
Mar 10, 2018·Diseases of the Colon and Rectum·Mitsuro KandaUNKNOWN Japanese Foundation for Multidisciplinary Treatment of Cancer
Aug 11, 2020·Surgical Pathology Clinics·Melanie Johncilla, Rhonda K Yantiss
Jun 26, 2021·Cancer Management and Research·Qing HuangJie Cao

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