Mismatch repair deficiency may affect clinical outcome through immune response activation in metastatic gastric cancer patients receiving first-line chemotherapy

Gastric Cancer : Official Journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association
Riccardo GiampieriStefano Cascinu

Abstract

The microsatellite-instable gastric cancer subtype, because of its supposed high antigenic potential, is a promising candidate for immunotherapy. We analyzed if the presence of a defective mismatch repair (MMR) system is associated with other markers of immune response and their relationship with outcome in advanced gastric cancer patients. We analyzed the relationship between clinical outcome and MMR status, the presence of tumor-infiltrating lymphocytes (TIL), lymphocytosis, and neutrophil-to-lymphocyte ratio (NLR) in metastatic gastric cancer patients treated with a chemotherapy doublet in the first-line setting. Other stratification factors were sex, age, Eastern Cooperative Oncology Group performance status, adjuvant/neoadjuvant chemotherapy, metastatic sites, and histotype. One hundred three patients were eligible for analysis. Defective MMR was found in 15 patients (14 %), TILs were found in 18 patients (17 %), lymphocytosis was found in 24 patients (23 %), and high NLR was found in 75 patients (72 %). Significant correlations were found between defective MMR and TIL positivity (p = 0.0004), between defective MMR and lymphocytosis (p = 0.0062), between defective MMR and low NLR (p = 0.000069), and between TIL positivity ...Continue Reading

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Citations

Sep 26, 2016·Gastric Cancer : Official Journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association·Yeonjoo ChoiHyung-Ho Kim
Apr 25, 2018·The British Journal of Surgery·D ZengW Liao
Aug 16, 2017·World Journal of Gastrointestinal Oncology·Byung Woog KangAn Na Seo
Nov 15, 2018·International Journal of Surgical Pathology·Ameer HamzaZyad Kafri
Dec 1, 2018·International Journal of Cancer. Journal International Du Cancer·Georg Martin HaagMatthias Kloor
Jun 1, 2017·American Society of Clinical Oncology Educational Book·Ronan J Kelly
Nov 2, 2019·Journal of Pathology and Translational Medicine·Yoonjin KwakHye Seung Lee
Jan 18, 2018·Oncotarget·Kizuki YuzaToshifumi Wakai
Jun 22, 2019·Diagnostic Pathology·Basile Tessier-CloutierDavid F Schaeffer
Oct 3, 2018·Frontiers in Pharmacology·Vivek KumarAbhinav B Chandra
Dec 24, 2018·International Journal of Molecular Sciences·David VránaJanusz Jankowski
Jul 24, 2018·Therapeutic Advances in Medical Oncology·Michael FlynnNaureen Starling
May 6, 2019·International Journal of Cancer. Journal International Du Cancer·Jan BornscheinRebecca C Fitzgerald
Jan 21, 2017·BioMed Research International·Wei XuZhenggang Zhu
May 2, 2019·World Journal of Gastrointestinal Oncology·Yin HeXiao-Sheng Wang
Aug 18, 2020·Current Oncology Reports·Gretel Terrero, A Craig Lockhart
Oct 9, 2020·Pharmacogenomics·Khalil El Gharib, Hampig Raphael Kourie
Sep 18, 2020·Carcinogenesis·Melissa J ConroyJoanne Lysaght
Dec 4, 2020·Journal for Immunotherapy of Cancer·Siwen Hu-LieskovanHolden T Maecker
Mar 16, 2021·Cancer Treatment Reviews·Elisabetta PuligaSilvia Giordano
Apr 15, 2021·Clinics and Research in Hepatology and Gastroenterology·My-Linh Tran-MinhUNKNOWN for NORDICAP

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