Mismatch repair during homologous and homeologous recombination

Cold Spring Harbor Perspectives in Biology
Maria Spies, Richard Fishel

Abstract

Homologous recombination (HR) and mismatch repair (MMR) are inextricably linked. HR pairs homologous chromosomes before meiosis I and is ultimately responsible for generating genetic diversity during sexual reproduction. HR is initiated in meiosis by numerous programmed DNA double-strand breaks (DSBs; several hundred in mammals). A characteristic feature of HR is the exchange of DNA strands, which results in the formation of heteroduplex DNA. Mismatched nucleotides arise in heteroduplex DNA because the participating parental chromosomes contain nonidentical sequences. These mismatched nucleotides may be processed by MMR, resulting in nonreciprocal exchange of genetic information (gene conversion). MMR and HR also play prominent roles in mitotic cells during genome duplication; MMR rectifies polymerase misincorporation errors, whereas HR contributes to replication fork maintenance, as well as the repair of spontaneous DSBs and genotoxic lesions that affect both DNA strands. MMR suppresses HR when the heteroduplex DNA contains excessive mismatched nucleotides, termed homeologous recombination. The regulation of homeologous recombination by MMR ensures the accuracy of DSB repair and significantly contributes to species barriers du...Continue Reading

Citations

Dec 26, 2015·DNA Repair·Zhongdao LiPeggy Hsieh
Feb 4, 2016·Nature Communications·Maxwell W BrownIlya J Finkelstein
Mar 24, 2016·Protein & Cell·Qianlan XuXiaoyuan Song
Aug 25, 2015·Molecular Cell·Sabine TraverMarcel Méchali
May 1, 2016·Nucleic Acids Research·Ran ChenMarc S Wold
Aug 26, 2016·Scientific Reports·Jennifer A HollywoodPatrick T Harrison
Aug 31, 2016·FEMS Yeast Research·Ujani Chakraborty, Eric Alani
Jan 28, 2017·Nature Communications·A Castañeda-GarcíaJ Blázquez
Feb 23, 2017·Annual Review of Plant Biology·José M Gualberto, Kathleen J Newton
Apr 12, 2018·International Journal of Molecular Sciences·Jolene Michelle HelenaAnne Elisabeth Mercier
Feb 17, 2018·Neuro-oncology·Serah ChoiJoseph F Costello
Sep 22, 2018·The Journal of Biological Chemistry·William J GrahamRichard D Kolodner
Nov 8, 2017·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Isabel AlvesPhilip Awadalla
May 28, 2019·Current Genetics·Aurèle Piazza, Wolf-Dietrich Heyer
Apr 9, 2020·G3 : Genes - Genomes - Genetics·Daniele NovarinaMichael Chang
Jul 3, 2020·Biomarkers in Medicine·Xueli LiLiyun Jia
Aug 29, 2020·Critical Reviews in Biochemistry and Molecular Biology·Colleen C Caldwell, Maria Spies
Jul 15, 2015·The Journal of Biological Chemistry·Catherine E SmithRichard D Kolodner
Jun 5, 2019·Nature Medicine·Don P WolfShoukhrat M Mitalipov
Mar 8, 2017·Proceedings of the National Academy of Sciences of the United States of America·Nikki Bowen, Richard D Kolodner
Sep 28, 2016·Proceedings of the National Academy of Sciences of the United States of America·Shyamal SubramanyamMaria Spies
May 3, 2018·Nature Communications·Xueqing ZouSerena Nik-Zainal
Sep 5, 2019·International Journal of Molecular Sciences·Yan LiIshita Mukerji
Sep 12, 2015·The Journal of Biological Chemistry·Richard Fishel
Apr 27, 2019·Life Science Alliance·Angelika HeisslIrene Tiemann-Boege
May 7, 2020·Frontiers in Cellular and Infection Microbiology·Viviane Grazielle-SilvaSantuza M R Teixeira
Aug 26, 2020·JCI Insight·Mariano GolubickiSergi Castellví-Bel
Aug 3, 2019·Genes & Development·Justin B SteinfeldEric C Greene
Aug 1, 2018·Nature Structural & Molecular Biology·Eva M GoellnerRichard D Kolodner
Oct 4, 2018·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Kazuhito SatoHiroyuki Mano
Feb 14, 2021·Journal of Huntington's Disease·Ravi R Iyer, Anna Pluciennik
Feb 5, 2021·The Journal of Biological Chemistry·David R McKinzeyMichael A Trakselis
Jun 5, 2018·Journal of Molecular Biology·Jiaquan LiuRichard Fishel

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Cold Spring Harbor Perspectives in Biology
Maria Jasin, Rodney Rothstein
Nature Reviews. Genetics
Frédéric BaudatBernard de Massy
© 2022 Meta ULC. All rights reserved