Mismatch-specific anti-HLA antibody production following aorta transplants

Transplant International : Official Journal of the European Society for Organ Transplantation
M MirelliV Bonomini

Abstract

In this study, we have investigated the nature and magnitude of the immunological response after implantation of human aortic segments. Five recipients of aortic segment replacement were studied for anti-HLA antibody production (specificity and Ig class), CD3, CD4, and CD8 T cell subpopulation dynamics, and aortic wall thickness. Mismatch-specific IgG antibodies to HLA class I and HLA class II antigens were first detected 1-3 months after implantation and persisted in high concentrations for at least 1 year. Computer tomography scanning showed a progressive thickness of the aortic wall. Also the absolute number of CD3, CD4, and CD8 positive lymphocytes increased progressively after implantation. In conclusion, as was observed earlier for heart valve allografts, human implanted aortic segments induce a strong anti-HLA antibody response in recipients. We speculate that these antibodies have the potential to harm the implant, for example, by having an impact on luminal narrowing.

References

Aug 1, 1995·The Annals of Thoracic Surgery·J D SmithM H Yacoub
Sep 15, 1995·Transplantation·D PlissonnierJ B Michel
Jul 1, 1993·Arteriosclerosis and Thrombosis : a Journal of Vascular Biology·A MennanderP Häyry
Aug 1, 1996·The Journal of Thoracic and Cardiovascular Surgery·F HoekstraW Weimar
Oct 1, 1996·European Journal of Vascular and Endovascular Surgery : the Official Journal of the European Society for Vascular Surgery·A D Callow
Oct 1, 1996·European Journal of Immunogenetics : Official Journal of the British Society for Histocompatibility and Immunogenetics·A Nanni-CostaV Bonomini
Nov 1, 1996·The Journal of Thoracic and Cardiovascular Surgery·P HoganM F O'Brien
Feb 1, 1997·The Journal of Thoracic and Cardiovascular Surgery·I den HamerT Ebels

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Citations

Dec 28, 1999·European Journal of Vascular and Endovascular Surgery : the Official Journal of the European Society for Vascular Surgery·M MirelliM D'Addato
Sep 27, 2005·Transplantation Proceedings·M BuzziR Conte

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