PMID: 3744949Jul 1, 1986Paper

Misonidazole retention by normal tissues: a distinction between label on the ring and side chain

International Journal of Radiation Oncology, Biology, Physics
A J Franko, B M Garrecht

Abstract

The retention of misonidazole by mouse normal tissues and EMT6/Ed tumors was studied 24 hr after injection of ring labelled (2-14C) and side chain-labelled (3H) drug. Slightly more 3H than 14C was retained by tumors, but this was considered to be within experimental error of no difference. The ring label (14C) activity retained by tumors was 5-12 times greater than that retained by heart, kidney, brain, muscle and spleen. However, in the same animals, the side chain label (3H) was retained to an appreciably greater extent by the normal tissues, so that the ratio of activities retained in tumors and normal tissues was 3 to 4. This difference in discrimination between tumors and normal tissues implies that gamma-emitting or NMR-active analogues of misonidazole will detect hypoxia in tumors in situ more efficiently, if the active isotope is situated on the ring. The data also indicate that fragmentation products of the metabolism of misonidazole, which contain the side chain and exclude the 2-carbon, are responsible for 50-70% of the misonidazole retained by normal tissues when a side chain-label is used.

References

Jul 1, 1986·International Journal of Radiation Oncology, Biology, Physics·R C UrtasunC J Koch
Jun 1, 1985·International Journal of Radiation Oncology, Biology, Physics·J L Born, W M Hadley
Aug 1, 1984·International Journal of Radiation Oncology, Biology, Physics·A M Rauth
Aug 1, 1984·International Journal of Radiation Oncology, Biology, Physics·B R Smith, J L Born
May 16, 1983·Biochemical and Biophysical Research Communications·A J Varghese

❮ Previous
Next ❯

Citations

Apr 25, 2000·Nuclear Medicine and Biology·L VaragnoloE K Pauwels
Feb 1, 1990·International Journal of Radiation Oncology, Biology, Physics·L M CobbS Butler
Jul 1, 1986·International Journal of Radiation Oncology, Biology, Physics·A J Franko
Apr 1, 1989·International Journal of Radiation Oncology, Biology, Physics·L M Cobb, J Nolan

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cancer Metabolism

In order for cancer cells to maintain rapid, uncontrolled cell proliferation, they must acquire a source of energy. Cancer cells acquire metabolic energy from their surrounding environment and utilize the host cell nutrients to do so. Here is the latest research on cancer metabolism.

Related Papers

International Journal of Radiation Oncology, Biology, Physics
B R Smith, J L Born
International Journal of Radiation Oncology, Biology, Physics
R C UrtasunCameron J Koch
© 2021 Meta ULC. All rights reserved