Misoprostol in addition to routine treatment of postpartum hemorrhage: a hospital-based randomized-controlled trial in Karachi, Pakistan.

BMC Pregnancy and Childbirth
Nadeem F ZuberiG Walraven

Abstract

Postpartum hemorrhage (PPH) remains a major killer of women worldwide. Standard uterotonic treatments used to control postpartum bleeding do not always work and are not always available. Misoprostol's potential as a treatment option for PPH is increasingly known, but its use remains ad hoc and available evidence does not support the safety or efficacy of one particular regimen. This study aimed to determine the adjunct benefit of misoprostol when combined with standard oxytocics for PPH treatment. A randomized controlled trial was conducted in four Karachi hospitals from December 2005 - April 2007 to assess the benefit of a 600 mcg dose of misoprostol given sublingually in addition to standard oxytocics for postpartum hemorrhage treatment. Consenting women had their blood loss measured after normal vaginal delivery and were enrolled in the study after losing more than 500 ml of blood. Women were randomly assigned to receive either 600 mcg sublingual misoprostol or matching placebo in addition to standard PPH treatment with injectable oxytocics. Both women and providers were blinded to the treatment assignment. Blood loss was collected until active bleeding stopped and for a minimum of one hour after PPH diagnosis. Total blood l...Continue Reading

Associated Clinical Trials

References

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Citations

Nov 1, 2012·BMC Pregnancy and Childbirth·Ali Mohammad MirSadaf Gull
Jan 25, 2014·Journal de gynécologie, obstétrique et biologie de la reproduction·A Garrigue, F Pierre
Jan 12, 2012·Expert Opinion on Investigational Drugs·Wendy R SheldonBeverly Winikoff
Oct 6, 2012·International Journal of Gynaecology and Obstetrics : the Official Organ of the International Federation of Gynaecology and Obstetrics·UNKNOWN International Federation Of Gynecology And Obstetrics
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Dec 28, 2021·Journal of Obstetrics and Gynaecology : the Journal of the Institute of Obstetrics and Gynaecology·Tawakwallit A OttunHaleemat F Olalere

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Methods Mentioned

BETA
blood collection
hysterectomies

Software Mentioned

SPSS
Epi Info ( Epi Info
Statistical Package for the Social Sciences

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