Misoprostol treatment exacerbates abdominal discomfort in patients with non-ulcer dyspepsia and erosive prepyloric changes. A double-blind, placebo-controlled, multicentre study

Scandinavian Journal of Gastroenterology
T HauskenA Berstad

Abstract

One hundred and thirty-seven consecutive outpatients with non-ulcer dyspepsia (NUD) and erosive prepyloric changes (EPC) were randomly allocated to double-blind treatment with 400-micrograms misoprostol tablets twice daily or placebo for 4 weeks. Misoprostol had a significant worsening effect on epigastric pain, nausea, meteorism, lower abdominal pain, and diarrhoea, as compared with placebo. The fact that symptoms in patients with NUD and EPC were exacerbated by an antisecretory dose of misoprostol indicates that the symptoms are largely unrelated to gastric acid.

References

Aug 1, 1989·Scandinavian Journal of Gastroenterology·E Skoubo-KristensenE Amdrup
May 1, 1989·Scandinavian Journal of Gastroenterology·G Stene-LarsenA Berstad
Jun 1, 1985·Scandinavian Journal of Gastroenterology·A A Nesland, A Berstad
Mar 1, 1985·Scandinavian Journal of Gastroenterology·A Nesland, A Berstad

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Citations

Sep 7, 2000·Digestive and Liver Disease : Official Journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver·M KochL Capurso
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Apr 1, 1995·Alimentary Pharmacology & Therapeutics·N J Talley
Dec 7, 1992·The Medical Journal of Australia·C J Steadman

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