Misplacement of dysplastic epithelium in Peutz-Jeghers Polyps: the ultimate diagnostic pitfall?

The American Journal of Surgical Pathology
V C PetersenN A Shepherd


Peutz-Jeghers syndrome is characterized by multiple polyps throughout the gastrointestinal tract in association with mucocutaneous pigmentation. Small bowel polyps in the syndrome may exhibit epithelial misplacement, into the submucosa, the muscularis propria, and even the subserosa. The authors demonstrate two patients in whom there is also misplacement of dysplastic epithelium into the submucosa and muscularis propria of the small bowel. Epithelial misplacement is recognized to mimic invasive malignancy. Such mimicry is heightened substantially when the misplaced epithelium is dysplastic. Correct interpretation of the histologic changes is aided by the use of special stains, which demonstrate the associated lamina propria and the lack of a desmoplastic response, and immunohistochemistry, which shows that the misplaced dysplastic epithelium is accompanied by non-neoplastic mucosa. There is an increased prevalence of gastrointestinal malignancy in Peutz-Jeghers syndrome. However, the presence of perplexing histologic features, caused by epithelial misplacement, especially when some of that epithelium is dysplastic, in small bowel polyps at least has the potential for the overdiagnosis of malignancy in the syndrome.


Jan 1, 1978·American Journal of Clinical Pathology·M Kyriakos, S C Condon
Nov 1, 1989·Gut·A D SpigelmanR K Phillips
Dec 1, 1986·The American Journal of Surgical Pathology·R C Haggitt, B J Reid
Jun 11, 1987·The New England Journal of Medicine·F M GiardielloG D Luk
Oct 1, 1987·The American Journal of Surgical Pathology·N A ShepherdJ R Jass
Jan 1, 1987·The American Journal of Surgical Pathology·T NaritaT Ito
Apr 1, 1985·The American Journal of Surgical Pathology·L H Sobin
Jan 1, 1973·Journal of Clinical Pathology·T MutoB C Morson
Nov 1, 1970·Gut·H J Bussey
Jan 5, 1970·JAMA : the Journal of the American Medical Association·R G Sommerhaug, T Mason
Sep 1, 1981·Archives of Surgery·D A LinosL G Bartholomew
Oct 1, 1993·Diseases of the Colon and Rectum·K HizawaM Fujishima
Jul 1, 1954·American Journal of Surgery·D BRAYTON, W J NORRIS

❮ Previous
Next ❯


Jan 31, 2013·Der Pathologe·J FriemelA Weber
Feb 26, 2010·Journal of Medical Case Reports·Sayantan BhattacharyaGeorge Mathew
Jan 7, 2015·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Neil A Shepherd, Rebecca K L Griggs
Jul 24, 2002·Gastroenterology Clinics of North America·Marian M Haber
Oct 1, 2003·American Journal of Medical Genetics. Part a·Mary P Bronner
Nov 11, 2014·Journal of Surgical Oncology·Thereasa A RichBanu Arun
Mar 21, 2007·Virchows Archiv : an International Journal of Pathology·Gaetano MagroPaolo Greco
Jan 7, 2010·The American Journal of Gastroenterology·M G F van LierM E van Leerdam
Mar 28, 2013·Pathology International·Haruka OkadaMitsugu Ishizawa
Oct 28, 2014·Histopathology·Marco Novelli
Mar 27, 2004·Archives of Pathology & Laboratory Medicine·Bobby L Boyanton, Stephen S Shinault

❮ Previous
Next ❯

Related Concepts

Related Feeds

Barrett Esophagus

Barrett’s esophagus if a serious complication of gastroesophageal reflux disease during which the normal esophageal lining changes to tissue that resembles intestinal lining. Here is the latest research.