Missed opportunities for prevention of vertical HIV transmission in Canada, 1997-2016: a surveillance study.

CMAJ Open
Ari BitnunCanadian Perinatal HIV Surveillance Program

Abstract

Vertical HIV transmission has declined in Canada, but missed opportunities for prevention continue to occur. We sought to determine the adequacy, and changes over time in adequacy, of uptake of maternal and neonatal antiretroviral therapy for the prevention of vertical HIV transmission, and to determine the vertical transmission rate over time and according to adequacy of antenatal antiretroviral therapy during the combination antiretroviral therapy era in Canada. The Canadian Perinatal HIV Surveillance Program collects data annually through retrospective chart review concerning HIV-infected women and their infants. We determined receipt of adequate antiretroviral treatment (antenatal combination antiretroviral treatment for ≥ 4 wk, intrapartum intravenous zidovudine treatment and 4-6 wk of infant oral zidovudine treatment) and predictors of inadequate antenatal combination antiretroviral therapy (none or < 4 wk) in Canada in 1997-2016. We identified 3785 mother-infant pairs. Uptake of 4 weeks or more of antenatal combination antiretroviral therapy increased over time across all provinces/territories and regardless of maternal race/ethnicity or risk category (p < 0.001). During 2011-2016, 92 women (6.5%) received no or less tha...Continue Reading

References

Dec 22, 2007·AIDS·Josiane WarszawskiUNKNOWN ANRS French Perinatal Cohort
Sep 9, 2011·Antiviral Therapy·UNKNOWN European Collaborative Study in EuroCoordClaire Thorne
Jan 3, 2012·AIDS·John C ForbesUNKNOWN Canadian Pediatric AIDS Research Group (CPARG)
Jul 24, 2012·International Journal of Gynaecology and Obstetrics : the Official Organ of the International Federation of Gynaecology and Obstetrics·Jennifer S ReadUNKNOWN NISDI Perinatal/LILAC Study Group
Aug 29, 2012·The Pediatric Infectious Disease Journal·Luis Manuel PrietoUNKNOWN Madrid Cohort of HIV-Infected Mother-Infant Pairs
May 24, 2014·The Canadian Journal of Infectious Diseases & Medical Microbiology = Journal Canadien Des Maladies Infectieuses Et De La Microbiologie Médicale·Ari BitnunDeborah Money
Sep 16, 2014·Journal of Obstetrics and Gynaecology Canada : JOGC = Journal D'obstétrique Et Gynécologie Du Canada : JOGC·Deborah MoneyUNKNOWN SPECIAL CONTRIBUTORS
Jul 23, 2015·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Laurent MandelbrotUNKNOWN ANRS-EPF Study Group
Aug 6, 2015·AIDS·Andres F Camacho-GonzalezRana Chakraborty
Nov 4, 2015·CMAJ : Canadian Medical Association Journal = Journal De L'Association Medicale Canadienne·Corinne A RiddellLeanne S Dahlgren
Mar 10, 2017·Obstetrics and Gynecology·Gwendolyn B ScottUNKNOWN International Maternal Pediatric Adolescent AIDS Clinical Trials Group (IMPAACT) P1025 Study Team
Mar 21, 2017·JAMA Pediatrics·Allan W TaylorPatricia Sweeney

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Citations

Jun 13, 2019·BJOG : an International Journal of Obstetrics and Gynaecology·D MoneyUNKNOWN Canadian Perinatal HIV Surveillance Program
Feb 6, 2020·Canadian Journal of Public Health = Revue Canadienne De Santé Publique·Sabrina S PlittCarmen L Charlton
Jan 20, 2021·Child Neuropsychology : a Journal on Normal and Abnormal Development in Childhood and Adolescence·Julia M YoungMary Lou Smith
Oct 30, 2021·The Pediatric Infectious Disease Journal·Shu Nan Jessica LiLaura Sauvé

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