PMID: 3828969Apr 1, 1987

Missing Y chromosomes in lymph nodes from patients with non-Hodgkin's lymphoma

Cancer Genetics and Cytogenetics
B J BatemanJ O Armitage

Abstract

Five of 86 male patients with non-Hodgkin's lymphoma had chromosomally abnormal clones in their lymph nodes, which involved a missing Y chromosome. The loss of the Y chromosome was confined to the malignant cells when normal cells were present. The patients ranged in age from 41 to 85 years. All five patients had B-cell lymphomas with the histologic subtype diffuse large cell in two patients and immunoblastic, follicular large cell and follicular mixed in a single patient each. The t(14; 18)(q32;q21) chromosome abnormality accompanied the missing Y chromosome in four of the five patients. It appears that Y chromosome loss is one of the secondary abnormalities associated with non-Hodgkin's lymphoma.

References

Jan 1, 1979·British Journal of Haematology·T Padre-MendozaE N Forman
Jul 1, 1985·Cancer Genetics and Cytogenetics·R I HolmesE J Freireich
Oct 1, 1972·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·M Sellyei, L Vass
Oct 1, 1971·British Journal of Haematology·L M Walker
Jul 1, 1970·British Journal of Haematology·M L O'RiordanI M Tough
Sep 1, 1984·Cancer Genetics and Cytogenetics·J J YunisM E Kaplan
Feb 22, 1964·Lancet·D E SPEED, S D LAWLER

Citations

Feb 1, 1989·Cancer Genetics and Cytogenetics·J ArnemannC Fonatsch
Feb 1, 1989·Cancer Genetics and Cytogenetics·T R DennisH Rappaport
Mar 1, 1990·Cancer Genetics and Cytogenetics·J A LoganR L Martuza
Nov 1, 1990·Cancer Genetics and Cytogenetics·I PowellE Kleer
Jul 1, 1993·Cancer Genetics and Cytogenetics·R D GordonJ C Rutherford
Jan 1, 1994·Cancer Genetics and Cytogenetics·C B RiskeA A Sandberg
Jun 1, 1992·The Journal of Hand Surgery : Journal of the British Society for Surgery of the Hand·A V BonniciA C Berry
Sep 19, 2000·Cancer Genetics and Cytogenetics·T S WanS Y Ha
Dec 1, 1994·Cancer·M LishnerA Klein
Feb 27, 1993·BMJ : British Medical Journal·H M FidlerJ McFadden
Feb 20, 1991·International Journal of Cancer. Journal International Du Cancer·P PeltomäkiA de la Chapelle
Jan 2, 1991·International Journal of Cancer. Journal International Du Cancer·L Doneda, L Larizza
Aug 1, 1995·Genes, Chromosomes & Cancer·R SultanaC M Disteche

Related Concepts

Partial Monosomy
Karyotype Determination Procedure
Lymph Nodes
Reticulosarcoma
Y Chromosome

Related Feeds

Blood And Marrow Transplantation

The use of hematopoietic stem cell transplantation or blood and marrow transplantation (bmt) is on the increase worldwide. BMT is used to replace damaged or destroyed bone marrow with healthy bone marrow stem cells. Here is the latest research on bone and marrow transplantation.

B-Cell Lymphoma

B-cell lymphomas include lymphomas that affect B cells. This subtype of cancer accounts for over 80% of non-Hodgkin lymphomas in the US. Here is the latest research.