Mite-Allergic Rhinitis: How to Evaluate Clinical Efficacy in Allergen-Specific Immunotherapy Trials?

Current Treatment Options in Allergy
Oliver Pfaar, R Gerth van Wijk

Abstract

House dust mite (HDM) allergen exposure is the most important cause of perennial allergic rhinitis and/or asthma. Although allergen-specific immunotherapy (AIT) with HDM is well established, published studies have been characterized by substantial heterogeneity in clinical endpoints. Standardization in measuring clinical efficacy is required. Moreover, when designing an AIT trial with HDM allergens, several considerations have to be taken into account. The history of HDM allergy is less clear cut than the typical history of pollen allergy. In addition, clinical features of HDM allergy may differ from those of pollen allergy. Moreover, although not easily measurable, fluctuation in allergen exposure may cause variation in symptom severity and determine the timing of assessment of clinical effects of HDM AIT. Key points 1. A combined symptom and medication score (CSMS) is recommended as standard for the primary endpoint in future house dust mite (HDM) allergen-specific immunotherapy trials. 2. The diagnosis of HDM allergy is based on a carefully taken history in combination with sensitization to HDM allergens. 3. Eye symptoms are less prominent in patients with HDM-induced allergic rhinitis. Nasal symptoms, but not eye symptoms, ...Continue Reading

References

Jan 1, 1991·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·E F Juniper, G H Guyatt
Feb 1, 1985·Allergy·H Mosbech
Feb 1, 1994·The Journal of Allergy and Clinical Immunology·S van der HeideH F Kauffman
Nov 5, 1998·The Journal of Allergy and Clinical Immunology·J BousquetH J Malling
Jun 3, 1999·Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology·D MunganL Gürbüz
Nov 15, 2001·The Journal of Allergy and Clinical Immunology·J BousquetUNKNOWN World Health Organization
Aug 23, 2002·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·I TerreehorstR Gerth van Wijk
Jun 6, 2003·Pediatric Allergy and Immunology : Official Publication of the European Society of Pediatric Allergy and Immunology·Flora IppolitiTullio Frediani
Jul 18, 2003·The New England Journal of Medicine·Ingrid TerreehorstRoy Gerth van Wijk
Aug 13, 2003·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·V A VarneyA J Frew
Apr 22, 2004·The Journal of Allergy and Clinical Immunology·Piero MaestrelliUNKNOWN Regione Veneto Study Group on the "Effect of immunotherapy in allergic asthma"
Sep 24, 2005·Pediatric Allergy and Immunology : Official Publication of the European Society of Pediatric Allergy and Immunology·F MarcucciS E Burastero
Jan 3, 2006·The Journal of Allergy and Clinical Immunology·Jean BousquetBashar Allaf
Dec 15, 2006·Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology·Maciej CiebiadaPaweł Górski
Feb 14, 2007·Pediatric Allergy and Immunology : Official Publication of the European Society of Pediatric Allergy and Immunology·Nhân Pham-ThiClaude Andre
Aug 22, 2009·American Journal of Respiratory and Critical Care Medicine·Robyn E O'HehirAlessandra Sandrini
Jul 14, 2010·The Journal of Allergy and Clinical Immunology·Stefan ZielenEnzo Madonini
Jan 20, 2011·American Journal of Rhinology & Allergy·Herbert RiechelmannHuub A J Kleinjans
Feb 22, 2011·The Journal of Allergy and Clinical Immunology·Robert K BushWilliam W Busse
Oct 25, 2011·Pediatric Allergy and Immunology : Official Publication of the European Society of Pediatric Allergy and Immunology·Cindy M A de BotJohannes C van der Wouden
Apr 11, 2012·International Archives of Allergy and Immunology·J M KlossekA Didier
Sep 1, 2012·Clinical and Translational Allergy·Joao A FonsecaJean Bousquet
Nov 1, 2012·Clinical and Translational Allergy·Moises A CalderonNikolaos Papadopoulos
Nov 28, 2012·International Archives of Allergy and Immunology·Philippe Jean BousquetJean Bousquet
Jan 22, 2013·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·A BozekJ Jarzab
Oct 22, 2013·The Journal of Allergy and Clinical Immunology·Moises A CalderonPascal Demoly

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Citations

May 25, 2016·American Journal of Rhinology & Allergy·Xiang LiKunling Shen
Mar 16, 2017·Current Allergy and Asthma Reports·Harold S NelsonHendrik Nolte
Nov 14, 2018·International Archives of Allergy and Immunology·Olivia Joan Adams, Stephan von Gunten

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