MITF is necessary for generation of prostaglandin D2 in mouse mast cells

The Journal of Biological Chemistry
Eiichi Morii, Keisuke Oboki

Abstract

Mast cells generate eicosanoids that are linked to asthma and other inflammatory diseases. A basic-helix-loop-helix leucine zipper transcription factor termed MITF is essential for the development of mast cells. Although other substances also linked to inflammatory reactions (such as various proteases and serotonin) require MITF for their expression, the role of MITF in eicosanoid generation has not been studied. We examined eicosanoid generation in bone marrow-derived mast cells (BMMCs) of tg/tg mice that lack MITF. Most eicosanoids generated by BMMCs are either prostaglandin (PG) D2 or leukotriene C4. The former is synthesized via the cyclooxygenase pathway, whereas the latter is synthesized via the 5-lipoxygenase pathway. In response to stimulation with IgE and antigens, BMMCs of tg/tg mice synthesized leukotriene C4 normally. However, neither immediate nor delayed PGD2 production was detected in these BMMCs. This indicates that MITF is a transcription factor that specifically activates the cyclooxygenase pathway, but not the 5-lipoxygenase pathway. Significant decreases in expression of hematopoietic PGD2 synthase (hPGDS, a terminal synthase for PGD2) were observed at both mRNA and protein levels in tg/tg BMMCs. MITF transa...Continue Reading

References

Jan 1, 1989·Annual Review of Immunology·Y Kitamura
Nov 1, 1989·Immunology Today·R L Stevens, K F Austen
Aug 1, 1982·Proceedings of the National Academy of Sciences of the United States of America·E RazinK F Austen
Nov 15, 1994·Annals of the New York Academy of Sciences·M MurakamiK F Austen
Mar 17, 2000·Science·T MatsuokaS Narumiya
May 29, 2000·The Journal of Biological Chemistry·H InoueK Umesono
Dec 14, 2001·Biochemical and Biophysical Research Communications·E MoriiY Kitamura
Jan 22, 2002·The Journal of Immunology : Official Journal of the American Association of Immunologists·Bruno L DiazJonathan P Arm
Mar 29, 2002·International Archives of Allergy and Immunology·Yukihiko KitamuraAkihiko Ito
Sep 10, 2002·Molecular Immunology·Yukihiko KitamuraAkihiko Ito
Dec 21, 2002·The Journal of Biological Chemistry·Lixin LiRichard L Stevens
Aug 5, 2003·Prostaglandins, Leukotrienes, and Essential Fatty Acids·Yoshihide Kanaoka, Yoshihiro Urade

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Citations

Dec 10, 2009·Pigment Cell & Melanoma Research·Yann CheliCorine Bertolotto
Jun 9, 2006·Immunologic Research·Yoshimichi Okayama, Toshiaki Kawakami
Aug 7, 2007·International Journal of Hematology·Eiichi Morii
Mar 10, 2007·The Tohoku Journal of Experimental Medicine·Kazuhisa TakedaShigeki Shibahara
Mar 24, 2011·Drug Metabolism Reviews·Jack U Flanagan, Mark L Smythe
Aug 6, 2008·Biochemical and Biophysical Research Communications·Yusuke NiwaKo Okumura
Dec 13, 2005·Biochemical and Biophysical Research Communications·Kazuhisa TakedaShigeki Shibahara
Nov 29, 2005·Immunology Letters·J L Herlong, T R Scott
Feb 14, 2012·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Tian TianEiichi Morii
Jan 14, 2009·Laboratory Investigation; a Journal of Technical Methods and Pathology·Naoto NakamichiKatsuyuki Aozasa
May 28, 2019·Genes & Development·Colin R Goding, Heinz Arnheiter
Jan 17, 2020·Critical Reviews in Toxicology·Patrick E Hanna, M W Anders
Jul 31, 2012·International Journal of Oncology·Yoshiyuki SusakiEiichi Morii
Dec 22, 2006·The Journal of Immunology : Official Journal of the American Association of Immunologists·Amir H ShahlaeeClifford M Takemoto
Jan 2, 2021·The Journal of Allergy and Clinical Immunology·Pau RibóMargarita Martin
May 9, 2021·Trends in Immunology·Gökhan CildirDamon J Tumes
Jun 3, 2021·International Journal of Molecular Sciences·Yanru GuoMargarita Martin

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