PMID: 9429087Jan 16, 1998Paper

Mitigation of nitrofurantoin-induced toxicity in the perfused rat lung

Human & Experimental Toxicology
C E BernardB Hoener

Abstract

1. Nitrofurantoin is an antimicrobial agent which produces pulmonary toxicity via the redox cycling of the nitro group and its radical anion. This futile cycling triggers a complex series of events known collectively as oxidative stress. 2. In the isolated perfused rat lung, nitrofurantoin induced a decrease in tissue levels of glutathione but not protein thiols by the end of the 180 min experiment. There was no decline in tissue levels of angiotensin converting enzyme (a marker of cell disruption). However, edema was extensive as monitored in real time by weight gain (2.71 +/- 0.56 g vs 0.63 +/- 0.53 g in control, P < 0.05, n = 4) and lung mechanical functioning. The edema was matched by an increase in lavage proteins (85 +/- 15 mg vs 16 +/- 9 mg in controls, P < 0.05, n = 4). Electron microscopic examination of tissue indicated that the endothelial cells were detached from the basement membrane which would account for the edema. 3. Co-infusion of penicillamine, N-acetylcysteine or N-(2-mercaptopropionyl)-glycine which can protect tissue from oxidative stress failed to mitigate NFT-induced edema. Allopurinol, an inhibitor of xanthine oxidase and a metal chelator, significantly decreased weight gain but did not prevent the loss...Continue Reading

References

Oct 1, 1975·Canadian Journal of Microbiology·D R McCallaM L Fan
Mar 1, 1979·Biochemical Pharmacology·M R BoydH A Sasame
Jul 1, 1992·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·L M Matrisian
Sep 1, 1991·Journal of Applied Physiology·A M Lauzon, J H Bates
Jul 1, 1991·Journal of Applied Physiology·M S LudwigP V Romero
Feb 15, 1986·Biochemical Pharmacology·R F MinchinM R Boyd
Aug 15, 1988·Biochemical Pharmacology·L RossiP J O'Brien
Nov 13, 1969·The New England Journal of Medicine·F J HaileyW F Hewitt
Apr 1, 1983·The American Review of Respiratory Disease·W J Martin
Jun 1, 1981·Clinical Pharmacology and Therapeutics·B Hoener, S E Patterson
May 1, 1996·Human & Experimental Toxicology·W Shen, B Hoener
Oct 27, 1997·Journal of Pharmacological and Toxicological Methods·C E BernardB Hoener

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Citations

Dec 19, 2001·Archives of Biochemistry and Biophysics·Catherine MillerRonald P Mason

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