Mitochondria and α-Synuclein: Friends or Foes in the Pathogenesis of Parkinson's Disease?

Genes
Gaia FaustiniArianna Bellucci

Abstract

Parkinson's disease (PD) is a movement disorder characterized by dopaminergic nigrostriatal neuron degeneration and the formation of Lewy bodies (LB), pathological inclusions containing fibrils that are mainly composed of α-synuclein. Dopaminergic neurons, for their intrinsic characteristics, have a high energy demand that relies on the efficiency of the mitochondria respiratory chain. Dysregulations of mitochondria, deriving from alterations of complex I protein or oxidative DNA damage, change the trafficking, size and morphology of these organelles. Of note, these mitochondrial bioenergetics defects have been related to PD. A series of experimental evidence supports that α-synuclein physiological action is relevant for mitochondrial homeostasis, while its pathological aggregation can negatively impinge on mitochondrial function. It thus appears that imbalances in the equilibrium between the reciprocal modulatory action of mitochondria and α-synuclein can contribute to PD onset by inducing neuronal impairment. This review will try to highlight the role of physiological and pathological α-synuclein in the modulation of mitochondrial functions.

References

Sep 29, 1989·Biochemical and Biophysical Research Communications·Y MizunoY Kagawa
Dec 1, 1989·Annals of Neurology·W D ParkerJ K Parks
Jun 3, 1989·Lancet·A H SchapiraC D Marsden
Jul 1, 1989·Lancet·L A BindoffD M Turnbull
Jan 1, 1994·Journal of Neural Transmission. Parkinson's Disease and Dementia Section·C MytilineouM D Yahr
Aug 28, 1997·Nature·M G SpillantiniM Goedert
Apr 18, 1998·Neuroscience Letters·K WakabayashiH Takahashi
Feb 24, 2001·Annals of the New York Academy of Sciences·M G Spillantini, M Goedert
Oct 12, 2002·Proceedings of the National Academy of Sciences of the United States of America·William DauerRene Hen
Jun 20, 2003·Neuropharmacology·Kumlesh K DevHerman van der Putten
Aug 19, 2003·The Journal of Biological Chemistry·George K TofarisMaria Grazia Spillantini
Sep 29, 2004·Lancet·Marie-Christine Chartier-HarlinAlain Destée
Jul 12, 2005·Neurobiology of Aging·María NietoTeresa Gómez-Isla
Nov 2, 2005·Molecular and Cellular Biology·Christopher E EllisRobert L Nussbaum
Nov 22, 2005·Neurobiology of Disease·Peter KlivenyiM Flint Beal
May 12, 2006·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Paula M KeeneyJames P Bennett
Oct 27, 2007·Movement Disorders : Official Journal of the Movement Disorder Society·Christopher H Hawkes
Dec 7, 2007·Brain Research·W Davis ParkerRussell H Swerdlow
Mar 7, 2008·Cellular and Molecular Life Sciences : CMLS·M S PariharP Ghafourifar
Jul 9, 2008·Current Opinion in Neurology·Alexis Elbaz, Frédéric Moisan
Jun 11, 2010·Brain : a Journal of Neurology·Pablo Garcia-ReitböckMaria Grazia Spillantini
Apr 15, 2011·The Journal of Biological Chemistry·Ken NakamuraRobert H Edwards
Jun 11, 2011·International Journal of Immunopathology and Pharmacology·R NisticòN Mercuri
Jun 21, 2011·Neurobiology of Disease·Kenjiro OnoMasahito Yamada
Dec 23, 2011·Parkinsonism & Related Disorders·Vernice Jackson-LewisSerge Przedborski
Jan 10, 2012·Cold Spring Harbor Perspectives in Medicine·Kim Tieu
Sep 26, 2012·Movement Disorders : Official Journal of the Movement Disorder Society·J Paul Bolam, Eleftheria K Pissadaki
Dec 25, 2012·Journal of Neurology·Maria G CersosimoEduardo E Benarroch
Jan 2, 2014·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Cristina Guardia-LaguartaSerge Przedborski
May 17, 2014·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Richard I Morimoto, Ana Maria Cuervo
Jul 18, 2014·Antiviral Therapy·Brendan A I PaynePatrick F Chinnery

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Citations

Apr 21, 2019·Journal of Neurochemistry·Amir Tayaranian MarvianTiago Fleming Outeiro
May 14, 2020·The FEBS Journal·Patrícia I Santos, Tiago F Outeiro
Oct 24, 2018·Pharmaceuticals·Marco T Nuñez, Pedro Chana-Cuevas
May 30, 2019·Translational Neurodegeneration·Edoardo ParrellaMarina Pizzi
Apr 25, 2020·Nature Communications·Milica BozicJosé Manuel Valdivielso
Dec 25, 2019·Oxidative Medicine and Cellular Longevity·Gaia FaustiniArianna Bellucci
Jul 25, 2019·International Journal of Molecular Sciences·Ryu YamanakaKotaro Oka
Apr 8, 2020·Frontiers in Aging Neuroscience·Sarah M HernandezAndrey L Karamyshev
Nov 17, 2019·International Journal of Molecular Sciences·Kai-Jung LinTsu-Kung Lin
Dec 3, 2020·Frontiers in Cell and Developmental Biology·Yu-Mi JeonHyung-Jun Kim
Oct 27, 2020·Frontiers in Cellular and Infection Microbiology·Krishnaveni MohareerSharmistha Banerjee
Mar 9, 2021·Frontiers in Immunology·Tizibt Ashine BogaleArianna Bellucci
Jun 26, 2020·Neurotoxicology·Michelle R Joyce, Kathleen F Holton
Apr 17, 2021·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Zhi-Qi LiuBin Xu
Sep 12, 2021·The Journal of Immunology : Official Journal of the American Association of Immunologists·Hannah ScheiblichMichael T Heneka
Nov 5, 2021·Nature·Patricia González-RodríguezD James Surmeier

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Methods Mentioned

BETA
gene knockout

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