PMID: 9523706Apr 2, 1998Paper

Mitochondria and apoptosis

European Journal of Biochemistry
B Mignotte, J L Vayssiere

Abstract

Programmed cell death serves as a major mechanism for the precise regulation of cell numbers and as a defense mechanism to remove unwanted and potentially dangerous cells. Despite the striking heterogeneity of cell death induction pathways, the execution of the death program is often associated with characteristic morphological and biochemical changes, and this form of programmed cell death has been termed apoptosis. Genetic studies in Caenorhabditis elegans had led to the identification of cell death genes (ced). The genes ced-3 and ced-4 are essential for cell death; ced-9 antagonizes the activities of ced-3 and ced-4, and thereby protects cells that should survive from any accidental activation of the death program. Caspases (cysteine aspartases) are the mammalian homologues of CED-3. CED-9 protein is homologous to a family of many members termed the Bcl-2 family (Bcl-2s) in reference to the first discovered mammalian cell death regulator. In both worm and mammalian cells, the antiapoptotic members of the Bcl-2 family act upstream of the execution caspases somehow preventing their proteolytic processing into active killers. Two main mechanisms of action have been proposed to connect Bcl-2s to caspases. In the first one, anti...Continue Reading

Citations

Jan 14, 1999·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·B K SiesjöT Kristìan
Jun 12, 1999·Thyroid : Official Journal of the American Thyroid Association·F Labat-MoleurA Negoescu
Jun 17, 1999·FEBS Letters·C StefanelliC M Caldarera
Feb 26, 1999·The Journal of Biological Chemistry·P GhafourifarC Richter
Apr 15, 1999·European Journal of Clinical Investigation·A G Hall
May 10, 2000·The Journal of Nutrition·P J FrakerT L Vollmer
Dec 22, 2000·The Journal of Biological Chemistry·T YuG L McLendon
Feb 17, 2001·American Journal of Physiology. Heart and Circulatory Physiology·T YamamuraH Imamura
Oct 2, 2001·American Journal of Medical Genetics·S Raha, B H Robinson
Jan 25, 2002·Annual Review of Pharmacology and Toxicology·Carl D Bortner, John A Cidlowski
Mar 9, 2002·Breast Cancer Research and Treatment·Maryanne C S HerzigJan M Woynarowski
Nov 5, 2003·Journal of Cellular and Molecular Medicine·Elena MoldoveanuAdriana Colita
Jan 22, 2005·Annals of the New York Academy of Sciences·Mei-Hua LiYoung-Joon Surh
Sep 1, 2005·Apoptosis : an International Journal on Programmed Cell Death·N Hail
May 26, 2006·Acta Pharmacologica Sinica·Young-Jin ImDong-Soon Im
Jul 20, 2006·Apoptosis : an International Journal on Programmed Cell Death·N HailR Lotan
Feb 23, 2007·The Journal of Pharmacology and Experimental Therapeutics·Soo Bin YimChung Soo Lee
Apr 4, 2007·Annals of the New York Academy of Sciences·Hyo Jin KimHyong Joo Lee
Sep 1, 2007·Clinical & Experimental Ophthalmology·Andrew M Thompson
Jul 5, 2007·Journal of Zhejiang University. Science. B·Qi-xian LaiBi-zeng Mao
Feb 6, 2008·The Journal of Veterinary Medical Science·Hisato Obara, Ryô Harasawa
Feb 26, 2008·Free Radical Research·Yves NzenguePascale Guiraud
Sep 18, 2008·Journal of Assisted Reproduction and Genetics·Wojciech GlabowskiRafal Kurzawa
Jul 2, 2009·Clinical and Experimental Pharmacology & Physiology·Bao-Feng YangZhi-Guo Wang
Apr 1, 2008·The Korean Journal of Physiology & Pharmacology : Official Journal of the Korean Physiological Society and the Korean Society of Pharmacology·Yun Jeong Kim, Chung Soo Lee
Dec 7, 2010·Scandinavian Journal of Gastroenterology·Qinghui ZhuMing Zong
Jun 12, 2013·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Neil W Blackstone

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