Sep 9, 2019

Mitochondria and Critical Illness

Chest
Gerald S SupinskiLeigh Ann Callahan

Abstract

Classically, mitochondria have largely been believed to influence the development of illness by modulating cell metabolism and determining the rate of production of high-energy phosphate compounds (eg, adenosine triphosphate). It is now recognized that this view is simplistic and that mitochondria play key roles in many other processes, including cell signaling, regulating gene expression, modulating cellular calcium levels, and influencing the activation of cell death pathways (eg, caspase activation). Moreover, these multiple mitochondrial functional characteristics are now known to influence the evolution of cellular and organ function in many disease states, including sepsis, ICU-acquired skeletal muscle dysfunction, acute lung injury, acute renal failure, and critical illness-related immune function dysregulation. In addition, diseased mitochondria generate toxic compounds, most notably released mitochondrial DNA, which can act as danger-associated molecular patterns to induce systemic toxicity and damage multiple organs throughout the body. This article reviews these evolving concepts relating mitochondrial function and acute illness. The discussion is organized into four sections: (1) basics of mitochondrial physiology; ...Continue Reading

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Mentioned in this Paper

Patterns
Mitochondrial Inheritance
DNA, Mitochondrial
Kidney Failure, Acute
Organ
Intercellular Communication Process
Intensive Care Unit
Calcium Channel Activity
Mitochondria
Regulation of Immune System Process

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