Mitochondria and redox homoeostasis as chemotherapeutic targets of Araucaria angustifolia (Bert.) O. Kuntze in human larynx HEp-2 cancer cells

Chemico-biological Interactions
Cátia dos Santos BrancoMirian Salvador

Abstract

Natural products are among one of the most promising fields in finding new molecular targets in cancer therapy. Laryngeal carcinoma is one of the most common cancers affecting the head and neck regions, and is associated with high morbidity rate if left untreated. The aim of this study was to examine the antiproliferative effect of Araucaria angustifolia on laryngeal carcinoma HEp-2 cells. The results showed that A. angustifolia extract (AAE) induced a significant cytotoxicity in HEp-2 cells compared to the non-tumor human epithelial (HEK-293) cells, indicating a selective activity of AAE for the cancer cells. A. angustifolia extract was able to increase oxidative damage to lipids and proteins, and the production of nitric oxide, along with the depletion of enzymatic antioxidant defenses (superoxide dismutase and catalase) in the tumor cell line. Moreover, AAE was able to induce DNA damage, nuclear fragmentation and chromatin condensation. A significant increase in the Apoptosis Inducing Factor (AIF), Bax, poly-(ADP-ribose) polymerase (PARP) and caspase-3 cleavage expression were also found. These effects could be related to the ability of AAE to increase the production of reactive oxygen species through inhibition of the mitoc...Continue Reading

References

Mar 1, 1988·Experimental Cell Research·N P SinghE L Schneider
Jun 1, 1966·The Biochemical Journal·E D Wills
Apr 3, 1981·Science·L C GreenP Goldman
Aug 15, 1997·The Biochemical Journal·G M Cohen
May 13, 1999·Biochimica Et Biophysica Acta·R P PatelV M Darley-Usmar
Aug 29, 2001·Phytochemistry·S MongrandJ J Bessoule
Nov 26, 2002·Free Radical Biology & Medicine·Rafael RadiLaura Castro
Feb 24, 1956·Science·O WARBURG
Aug 6, 2005·The Journal of Pharmacology and Experimental Therapeutics·Cathleen CoverHartmut Jaeschke
Jun 6, 2006·Mass Spectrometry Reviews·Sílvia Lacorte, Amadeo R Fernandez-Alba
Oct 25, 2007·Biochemical Society Transactions·B Halliwell
Dec 9, 2008·The Biochemical Journal·Michael P Murphy
Mar 10, 2009·Genes & Development·Russell G Jones, Craig B Thompson
Jun 11, 2009·Archives of Biochemistry and Biophysics·Mohammad AtharArianna L Kim
May 22, 2010·Phytochemistry·Juliana Bello Baron MaurerFilomena Angela Pettolino
Jul 22, 2010·Pharmaceutical Biology·Helana N MichaelPaul W Paré
Jan 25, 2011·Nature Reviews. Cancer·Rob A CairnsTak W Mak
Feb 1, 2011·Fitoterapia·D ProcházkováN Wilhelmová
Mar 23, 2011·Nutrition Research·João R AraújoFátima Martel
Mar 25, 2011·Cancer Biology & Therapy·Jane K FauserGordon S Howarth
Oct 22, 2011·Biochimica Et Biophysica Acta·Ricardo LagoaCarlos Gutierrez-Merino
Mar 13, 2012·International Journal of Molecular Sciences·Cleva Villanueva, Robert D Kross
Apr 24, 2012·Trends in Pharmacological Sciences·Robin A J SmithMichael P Murphy
Nov 13, 2012·Current Drug Targets·Husain Yar KhanSheikh Mumtaz Hadi
Jan 25, 2013·Anti-cancer Agents in Medicinal Chemistry·Gustavo ScolaMirian Salvador
Mar 9, 2013·Cell Death & Disease·Y ZhaoM Tan
May 4, 2013·Phytomedicine : International Journal of Phytotherapy and Phytopharmacology·L C RufattoS Moura
May 31, 2013·World Journal of Surgical Oncology·Sheetal Korde ChoudhariVaishali Joshi
Nov 22, 2013·BMC Complementary and Alternative Medicine·Ravindran JaganathanShanthi Palanivelu
Apr 20, 2014·World Journal of Gastroenterology : WJG·Hsin-Chen LeeChin-Wen Chi
Apr 22, 2014·FEBS Letters·Mohd Askandar IqbalRameshwar N K Bamezai
May 31, 2014·Archives of Biochemistry and Biophysics·Cristian Sandoval-AcuñaHernán Speisky
Aug 12, 2014·Biochemical Society Transactions·Margaret M BriehlKristy Lee
Aug 27, 2014·Biochimica Et Biophysica Acta·Shyam Kankotia, Peter W Stacpoole
Sep 16, 2014·International Journal of Cancer. Journal International Du Cancer·Jacques FerlayFreddie Bray

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Citations

Jul 1, 2020·Journal of Environmental Science and Health. Part. B, Pesticides, Food Contaminants, and Agricultural Wastes·Gustavo A Bellatto, Welligton L Braguini
Jul 19, 2018·BioMed Research International·Gabriela GambatoMarli Camassola
Aug 17, 2018·Anti-cancer Agents in Medicinal Chemistry·Catia S BrancoMirian Salvador
Jun 3, 2021·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Kanchan BhardwajKamil Kuča
Feb 1, 2019·Chemical Research in Toxicology·Gabriela ChaufanNancy B Andrioli

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