Mitochondria-Associated Endoplasmic Reticulum Membranes in the Pathogenesis of Type 2 Diabetes Mellitus

Frontiers in Cell and Developmental Biology
Shanshan YangZhiguang Su

Abstract

The endoplasmic reticulum (ER) and mitochondria are essential intracellular organelles that actively communicate via temporally and spatially formed contacts called mitochondria-associated membranes (MAMs). These mitochondria-ER contacts are not only necessary for the physiological function of the organelles and their coordination with each other, but they also control the intracellular lipid exchange, calcium signaling, cell survival, and homeostasis in cellular metabolism. Growing evidence strongly supports the role of the mitochondria-ER connection in the insulin resistance of peripheral tissues, pancreatic β cell dysfunction, and the consequent development of type 2 diabetes mellitus (T2DM). In this review, we summarize current advances in the understanding of the mitochondria-ER connection and specifically focus on addressing a new perspective of the alterations in mitochondria-ER communication in insulin signaling and β cell maintenance.

References

Sep 8, 1995·Cell·P Camacho, J D Lechleiter
Aug 12, 2000·The Journal of Biological Chemistry·S J Stone, J E Vance
Aug 22, 2001·Molecular Biology of the Cell·E SmirnovaA M van der Bliek
Mar 5, 2004·Journal of Cell Science·Diana StojanovskiMichael T Ryan
Oct 2, 2004·The Journal of Biological Chemistry·Rie SugiokaYoshihide Tsujimoto
Jul 19, 2005·Nature Reviews. Molecular Cell Biology·Richard J Youle, Mariusz Karbowski
Sep 30, 2005·The Journal of Biological Chemistry·Carolina C P MendesM Fatima Leite
Sep 20, 2006·The Journal of Cell Biology·György CsordásGyörgy Hajnóczky
Oct 13, 2006·Nature·Mariusz KarbowskiRichard J Youle
Oct 20, 2006·The Journal of Biological Chemistry·Jun LiuVassilios Papadopoulos
Nov 7, 2006·Developmental Cell·David C Chan
Dec 15, 2006·Nature·Steven E KahnKristina M Utzschneider
Dec 21, 2006·The Journal of Cell Biology·György SzabadkaiRosario Rizzuto
Jun 8, 2007·The Journal of Biological Chemistry·Chuang-Rung Chang, Craig Blackstone
Feb 6, 2008·The Journal of Biological Chemistry·Mahuya BoseHimangshu S Bose
Apr 18, 2008·Molecular Biology of the Cell·Nathan MyhillThomas Simmen
Aug 13, 2008·The Journal of Cell Biology·Xiao-Jian HanMasayuki Matsushita
Oct 8, 2008·Proceedings of the National Academy of Sciences of the United States of America·G M CereghettiL Scorrano
Dec 5, 2008·Nature·Olga Martins de Brito, Luca Scorrano
Dec 9, 2008·The Biochemical Journal·Michael P Murphy
Feb 4, 2009·Antioxidants & Redox Signaling·David F Stowe, Amadou K S Camara
Mar 11, 2009·Frontiers in Bioscience (Landmark Edition)·Robert F FeissnerShey-Shing Sheu
Jun 17, 2009·Biochimica Et Biophysica Acta·György Csordás, György Hajnóczky
Dec 17, 2009·Antioxidants & Redox Signaling·Amadou K S CamaraDavid F Stowe
May 19, 2010·Cell·Dale W HaileyJennifer Lippincott-Schwartz
Jul 7, 2010·Molecular Cell·György CsordásGyörgy Hajnóczky
Oct 12, 2010·EMBO Reports·Cristina CerquaLuca Scorrano
Oct 30, 2010·Science·Carlotta GiorgiPier Paolo Pandolfi
Jan 25, 2011·Molecular Cell·Suzanne HoppinsJodi Nunnari
Jul 2, 2011·Cell Death and Differentiation·D De StefaniR Rizzuto
Aug 2, 2011·Cell Metabolism·Daniel C AnderssonAndrew R Marks

❮ Previous
Next ❯

Citations

Jun 3, 2021·Cells·Jesús BurilloCarlos Guillén

❮ Previous
Next ❯

Methods Mentioned

BETA
ubiquitination
protein folding
GTPases
GTPase

Related Concepts

Related Feeds

Calcium & Bioenergetics

Bioenergetic processes, including cellular respiration and photosynthesis, concern the transformation of energy by cells. Here is the latest research on the role of calcium in bioenergetics.