Mitochondria-Centric Review of Polyphenol Bioactivity in Cancer Models

Antioxidants & Redox Signaling
Jan F StevensClaudia S Maier

Abstract

Humans are exposed daily to polyphenols in milligram-to-gram amounts through dietary consumption of fruits and vegetables. Polyphenols are also available as components of dietary supplements for improving general health. Although polyphenols are often advertised as antioxidants to explain health benefits, experimental evidence shows that their beneficial cancer preventing and controlling properties are more likely due to stimulation of pro-oxidant and proapoptotic pathways. Recent Advances: The understanding of the biological differences between cancer and normal cell, and especially the role that mitochondria play in carcinogenesis, has greatly advanced in recent years. These advances have resulted in a wealth of new information on polyphenol bioactivity in cell culture and animal models of cancer. Polyphenols appear to target oxidative phosphorylation and regulation of the mitochondrial membrane potential (MMP), glycolysis, pro-oxidant pathways, and antioxidant (adaptive) stress responses with greater selectivity in tumorigenic cells. The ability of polyphenols to dissipate the MMP (Δψm) by a protonophore mechanism has been known for more than 50 years. However, researchers focus primarily on the downstream molecular effects ...Continue Reading

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Citations

Jul 1, 2020·Antioxidants & Redox Signaling·Gayle M GordilloChandan K Sen
Sep 27, 2020·International Journal of Molecular Sciences·Shalini ManiKeshav K Singh
Dec 15, 2020·Food Science & Nutrition·Injeong ChoJeong Hoon Cho
Jan 1, 2021·International Journal of Molecular Sciences·Miguel Olivas-AguirreOxana Dobrovinskaya
May 6, 2021·Journal of Cellular and Molecular Medicine·Shaozhuang LiuYongsheng Song
Jun 9, 2021·Critical Reviews in Food Science and Nutrition·Hanne VissenaekensJohn Van Camp
Jun 12, 2021·Food Research International·Hanne VissenaekensJohn Van Camp
Jun 26, 2021·The Plant Journal : for Cell and Molecular Biology·Armando Alcázar MagañaClaudia S Maier

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Datasets Mentioned

BETA
MDA-MB-231

Methods Mentioned

BETA
xenograft
ubiquitination

Software Mentioned

Advanced
Advanced Chemistry Development ( ACD / Labs )
SciFinder

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