Mitochondria could be a potential key mediator linking the intestinal microbiota to depression.

Journal of Cellular Biochemistry
Jiezhong Chen, Luis Vitetta

Abstract

The intestinal microbiota has been reported to affect depression, a common mental condition with severe health-related consequences. However, what mediates the effect of the intestinal microbiota on depression has not been well elucidated. We summarize the roles of the mitochondria in eliciting beneficial effects on the gut microbiota to ameliorate symptoms of depression. It is well known that mitochondria play a key role in depression. An important pathogenic factor, namely inflammatory response, may adversely impact mitochondrial functionality to maintain cellular homeostasis. Dysfunction of mitochondria not only affects neuronal function but also reduces neuron cell numbers. We posit that the intestinal microbiota could affect neuronal mitochondrial function through short-chain fatty acids such as butyrate. Brain inflammatory processes could also be affected through the modulation of gut permeability and blood lipopolysaccharide levels. Aberrant mitochondria functionality coupled to adverse cellular homeostasis could be a key mediator for the effect of the intestinal microbiota on the progression of depression.

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Citations

Jul 29, 2020·International Journal of Molecular Sciences·Jiezhong Chen, Luis Vitetta
Apr 4, 2021·International Journal of Molecular Sciences·Thomas M BarberMartin O Weickert
Aug 11, 2021·Journal of Clinical Neuroscience : Official Journal of the Neurosurgical Society of Australasia·Ali Mohammadkhanizadeh, Farnaz Nikbakht

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