Mitochondria-cytosol-nucleus crosstalk: learning from Saccharomyces cerevisiae

FEMS Yeast Research
Nicoletta GuaragnellaSergio Giannattasio

Abstract

Mitochondria are key cell organelles with a prominent role in both energetic metabolism and the maintenance of cellular homeostasis. Since mitochondria harbor their own genome, which encodes a limited number of proteins critical for oxidative phosphorylation and protein translation, their function and biogenesis strictly depend upon nuclear control. The yeast Saccharomyces cerevisiae has been a unique model for understanding mitochondrial DNA organization and inheritance as well as for deciphering the process of assembly of mitochondrial components. In the last three decades, yeast also provided a powerful tool for unveiling the communication network that coordinates the functions of the nucleus, the cytosol and mitochondria. This crosstalk regulates how cells respond to extra- and intracellular changes either to maintain cellular homeostasis or to activate cell death. This review is focused on the key pathways that mediate nucleus-cytosol-mitochondria communications through both transcriptional regulation and proteostatic signaling. We aim to highlight yeast that likely continues to serve as a productive model organism for mitochondrial research in the years to come.

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Citations

Mar 12, 2020·Journal of Molecular Evolution·Ľubomír Tomáška, Jozef Nosek
Aug 25, 2019·G3 : Genes - Genomes - Genetics·Natasa BosnjakFrank E Nargang
Mar 28, 2020·Korean Circulation Journal·Chang Myung OhYangsoo Jang
Jan 26, 2020·The FEBS Journal·Senthilkumar SivanesanJayakumar Rajadas
Jul 8, 2020·International Journal of Molecular Sciences·Karamat MohammadVladimir I Titorenko
Aug 6, 2019·Frontiers in Microbiology·Yinhe Mao, Changbin Chen
Nov 1, 2020·The Journal of Biological Chemistry·Urmimala BasuSmita S Patel
Nov 2, 2019·Mitochondrion·Carmela Vazquez-CalvoMartin Ott
Jan 29, 2021·The Biochemical Journal·Sandra Montella-ManuelMaria Angeles de la Torre-Ruiz
Jan 18, 2021·The Journal of Biological Chemistry·Urmimala BasuSmita S Patel
Jun 3, 2021·International Journal of Molecular Sciences·Vítězslav PlocekZdena Palková
Jul 31, 2021·Disease Markers·Siti Zulaikha Nashwa Mohd KhairAbdul Aziz Mohamed Yusoff

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