Mitochondria disease due to humidifier disinfectants: diagnostic criteria and its evidences

Environmental Analysis, Health and Toxicology
Jong Han Leem, Hwan-Cheol Kim

Abstract

Humidifier disinfectant damages caused by the misuse of humidifier disinfects, such as polyhexamethylene guanidine (PHMG), resulted in chemical disasters in South Korea in 2011. About four million people were exposed to humidifier disinfectants (HDs) in the 17 years between 1994 and 2011. Although fatal lung damage was initially reported, investigations into the victims' injuries revealed that the damage was not limited to the lungs, but that systemic damage was also confirmed. Considering the spread of HD from the lungs to the whole body, the toxic effects of PHMG from reactive oxygen species (ROS), NOTCH signaling pathways, and mitochondrial dysfunction resulted in endothelial damage in the lungs, blood vessels, liver, kidneys, bone marrow, nerves, and muscles. The main toxic mechanisms involved in HD damage may be the NOTCH pathway and mitochondrial damage. There are many case reports which include neurologic disorders (ADHD, depression, posttraumatic stress disorder), muscular disorder (exercise intolerance, myalgia), energy metabolism disorder (chronic fatigue syndrome), and immunologic disorder (rheumatoid arthritis) in HDs victims. These case reports involve multi-system involvement in HDs victims. Further well-designed ...Continue Reading

References

Nov 30, 2006·Neurology·E MoravaJ A M Smeitink
Mar 27, 2010·Proceedings of the National Academy of Sciences of the United States of America·Lakshmi R PerumalsamyApurva Sarin
Jan 30, 2014·The Journal of Biological Chemistry·Nandini Pal BasakSubrata Banerjee
May 8, 2015·Molecular Neurobiology·Chuen-Lin HuangNai-Kuei Huang
Feb 24, 2016·Current Diabetes Reviews·Jaakko SarparantaRajat Singh
Mar 30, 2016·Experimental Biology and Medicine·Chia-Chi HsuHsin-Chen Lee
May 27, 2016·Nature Reviews. Rheumatology·Ursula FearonDouglas J Veale
Nov 3, 2016·The Journal of Pathology·Charlotte L AlstonRobert W Taylor
Nov 18, 2016·The Journal of Toxicological Sciences·Ha-Ryong KimKyu-Hyuck Chung
Nov 30, 2016·BBA Clinical·Poonam VermaKochupurackal P Mohanakumar
Mar 25, 2017·Chest·Y S PrakashGary C Sieck
Sep 15, 2017·Tuberculosis and Respiratory Diseases·Won Young Kim, Sang Bum Hong
Sep 26, 2017·Molecular Genetics and Metabolism·Ayman W El-HattabFernando Scaglia
Oct 14, 2017·Environmental Health and Toxicology·Jong Han Leem, Jong-Hyeon Lee
Oct 31, 2017·Nature Reviews. Drug Discovery·Ana L MoraMoises Selman
Feb 21, 2018·Frontiers in Medicine·Daniel C ZankMauricio Rojas
Sep 28, 2018·Stem Cell Research & Therapy·Nayra CárdenesMauricio Rojas
Jul 25, 2019·Environmental and Molecular Mutagenesis·Nidhi SharmaAishwarya Prakash
Nov 11, 2019·Free Radical Biology & Medicine·Zhi HeMaryam Farzaneh
Feb 15, 2020·Annals of Translational Medicine·Lufei ZhangHaishan Jiang

❮ Previous
Next ❯

Related Concepts

Related Feeds

Anxiety Disorders

Discover the latest research on anxiety disorders including agoraphobia, panic disorder, obsessive-compulsive disorder, and post-traumatic stress disorder here.

Attention Disorders

Attention is involved in all cognitive activities, and attention disorders are reported in patients with various neurological diseases. Here are the latest discoveries pertaining to attention disorders.