Mitochondria get a Parkin' ticket.

Nature Cell Biology
Philipp Wild, Ivan Dikic

Abstract

Recent studies have revealed a prominent role of mitochondrial dysfunction in the development of one of the most common neurodegenerative disorders, Parkinson's disease. The ubiquitin ligase Parkin and the protein kinase PINK1, whose mutations are associated with Parkinson's disease, function in a pathway that links ubiquitylation with selective autophagy of damaged mitochondria.

References

Dec 10, 1999·Nature·P SutovskyG Schatten
Feb 2, 2006·Proceedings of the National Academy of Sciences of the United States of America·Clifford W Shults
Jan 31, 2008·Proceedings of the National Academy of Sciences of the United States of America·Angela C PooleLeo J Pallanck
Nov 26, 2008·The Journal of Cell Biology·Derek NarendraRichard J Youle
May 20, 2009·Molecular Cell·Vladimir KirkinIvan Dikic
Jun 26, 2009·Disease Models & Mechanisms·Jeehye ParkJongkyeong Chung
Jul 22, 2009·Developmental Cell·Tomotake KankiDaniel J Klionsky
Sep 24, 2009·Nature Reviews. Molecular Cell Biology·Ivan DikicKylie J Walters
Dec 8, 2009·Proceedings of the National Academy of Sciences of the United States of America·Cristofol Vives-BauzaSerge Przedborski
Dec 17, 2009·EMBO Reports·Ivana NovakIvan Dikic
Jan 26, 2010·Nature Cell Biology·Sven GeislerWolfdieter Springer

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Citations

Feb 3, 2012·Nature Cell Biology·Hemmo MeyerSebastian Bremer
Nov 16, 2011·Human Molecular Genetics·Yukiko KurodaTakao Mitsui
Feb 15, 2011·Genes & Development·Jessie Yanxiang GuoEileen White
Apr 22, 2011·Journal of Virology·Jianhua LiZhenghong Yuan
Jul 8, 2011·Cancer Prevention Research·Hsin-Yi Chen, Eileen White
Oct 15, 2011·PLoS Computational Biology·Jyh-Ying PengChun-Nan Hsu
Nov 17, 2015·International Journal of Molecular Sciences·Yoshimitsu Kiriyama, Hiromi Nochi
Jul 19, 2011·Mutation Research·Ester López-GallardoEduardo Ruiz-Pesini
Oct 19, 2010·Journal of Neurochemistry·Yasunari MunemasaSatoki Ueno
Aug 13, 2015·Nature·Noriyuki Matsuda, Keiji Tanaka
Jul 25, 2012·Experimental Gerontology·Sónia C CorreiaPaula I Moreira
Oct 5, 2010·Neurobiology of Disease·Yakup Batlevi, Albert R La Spada
Feb 11, 2015·DNA and Cell Biology·Sónia C CorreiaCláudia M Pereira
Jul 28, 2016·Biochimica Et Biophysica Acta·Sónia C CorreiaPaula I Moreira
Nov 13, 2018·Journal of Cellular Physiology·Farzaneh G TahrirKamel Khalili
Mar 1, 2018·Scientific Reports·Bjorn T TamParco M Siu
Mar 2, 2018·CNS Drugs·Alan J Fowler, Charbel E-H Moussa
Jul 19, 2011·Oncogene·W K K WuJ J Y Sung
Mar 16, 2017·Journal of Neurochemistry·Valeria AvdoshinaGaylia Jean Harry
Jul 3, 2013·Current Opinion in Neurology·Eleanna KaraHenry Houlden

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