Mitochondria in innate immune signaling

Translational Research : the Journal of Laboratory and Clinical Medicine
Balaji Banoth, Suzanne L Cassel

Abstract

Mitochondria are functionally versatile organelles. In addition to their conventional role of meeting the cell's energy requirements, mitochondria also actively regulate innate immune responses against infectious and sterile insults. Components of mitochondria, when released or exposed in response to dysfunction or damage, can be directly recognized by receptors of the innate immune system and trigger an immune response. In addition, despite initiation that may be independent from mitochondria, numerous innate immune responses are still subject to mitochondrial regulation as discrete steps of their signaling cascades occur on mitochondria or require mitochondrial components. Finally, mitochondrial metabolites and the metabolic state of the mitochondria within an innate immune cell modulate the precise immune response and shape the direction and character of that cell's response to stimuli. Together, these pathways result in a nuanced and very specific regulation of innate immune responses by mitochondria.

References

Mar 1, 1975·Proceedings of the National Academy of Sciences of the United States of America·E SchiffmannS M Wahl
May 16, 1990·Biochemical and Biophysical Research Communications·F BoulayP Vignais
Jan 1, 1990·International Review of Cytology·J Bereiter-Hahn
Jan 1, 1982·The Journal of Experimental Medicine·H Carp
Jan 1, 1997·Advances in Pharmacology·R D Ye, F Boulay
Jul 6, 2000·The Journal of Immunology : Official Journal of the American Association of Immunologists·N S ChandelP T Schumacker
Apr 20, 2001·Cytokine & Growth Factor Reviews·Y LeJ M Wang
Feb 28, 2002·Annual Review of Immunology·Charles A Janeway, Ruslan Medzhitov
Feb 26, 2004·Journal of Leukocyte Biology·L Vincent CollinsAndrej Tarkowski
Mar 25, 2004·Nature Reviews. Immunology·J David Lambeth
Oct 13, 2004·Nucleic Acids Research·Angela C Spencer, Linda L Spremulli
Jul 5, 2005·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Hagir B SulimanClaude A Piantadosi
Jul 9, 2005·The Journal of Immunology : Official Journal of the American Association of Immunologists·Hyun Kyu KangYoe-Sik Bae
Jul 26, 2005·Immunity·Hiroki KatoShizuo Akira
Aug 2, 2005·Cell Metabolism·Joslyn K BrunelleNavdeep S Chandel
Aug 30, 2005·Nature Immunology·Taro KawaiShizuo Akira
Sep 13, 2005·Molecular Cell·Liang-Guo XuHong-Bing Shu
Oct 8, 2005·The Journal of Immunology : Official Journal of the American Association of Immunologists·Simon RothenfusserKatherine A Fitzgerald
Oct 14, 2006·Science·Andreas PichlmairCaetano Reis e Sousa
Oct 14, 2006·Science·Veit HornungGunther Hartmann
Dec 26, 2006·Molecular Cell·Nicholas D BonawitzGerald S Shadel
Jan 18, 2007·Annual Review of Biochemistry·Michael T Ryan, Nicholas J Hoogenraad
Apr 13, 2007·Biochimie·Marie-Josèphe RabietFrançois Boulay
Jan 18, 2008·Nature·Chris B MooreJenny P-Y Ting
Jan 24, 2009·Proceedings of the National Academy of Sciences of the United States of America·Lijuan XuJun Gu
Feb 7, 2009·Proceedings of the National Academy of Sciences of the United States of America·Michal Caspi TalAkiko Iwasaki
May 6, 2009·Biochimica Et Biophysica Acta·Michael Schlame, Mindong Ren
May 13, 2009·Proceedings of the National Academy of Sciences of the United States of America·Wenxiang SunZhengfan Jiang
Jun 23, 2009·The Journal of Immunology : Official Journal of the American Association of Immunologists·Luigi FranchiGabriel Núñez

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Citations

Mar 25, 2019·The Journal of Immunology : Official Journal of the American Association of Immunologists·Simon LindHuamei Forsman
Nov 5, 2019·Current Pharmaceutical Design·George Anderson, Susana R Betancort Medina
Feb 12, 2020·The Journal of International Medical Research·Yang YangLizheng Qin
Aug 11, 2020·International Journal of Radiation Biology·Rong JiaYarong Du
Aug 30, 2020·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Ruihua MaKaren M Ridge
Sep 17, 2020·Pharmaceutics·Ana Isabel SebastiãoMaria Teresa Cruz
Nov 7, 2019·American Journal of Physiology. Lung Cellular and Molecular Physiology·Mahyar AghapourIrene H Heijink
Dec 10, 2019·Biological Chemistry·Bradford G HillVictor M Darley-Usmar
Aug 14, 2019·Frontiers in Pharmacology·Jack Uetrecht
Mar 27, 2020·Journal of Cellular and Molecular Medicine·Hideki MaedaSatoshi Gojo
Jun 2, 2020·Translational Neurodegeneration·Luodan YangQuanguang Zhang
Sep 6, 2019·Archives of Pharmacal Research·Hye-Youn Cho, Steven R Kleeberger
Mar 29, 2020·Biochemical Society Transactions·Rajdeep Das, Oishee Chakrabarti
Aug 9, 2020·International Journal of General Medicine·Johann Lechner, Wolfgang Mayer
Nov 9, 2018·Frontiers in Physiology·Yuxin ChenWang Min
Dec 20, 2020·Physiological Reports·Grégoire P MilletJohannes Burtscher
Dec 4, 2020·The Journal of Immunology : Official Journal of the American Association of Immunologists·Yangxi XiangKuntong Jia
Jan 8, 2021·Biochimica Et Biophysica Acta. General Subjects·Kai Yasukawa, Takumi Koshiba
Oct 6, 2020·IScience·Johannes BurtscherGrégoire P Millet
Dec 10, 2020·Immunity & Ageing : I & a·Alistair V W NunnJimmy D Bell
Dec 22, 2020·Frontiers in Cellular and Infection Microbiology·Tiia Snäkä, Nicolas Fasel
Oct 27, 2020·Frontiers in Pharmacology·Simone PatergnaniAlessandro Rimessi
Dec 22, 2020·Oncoimmunology·Adriana PetrazzuoloGuido Kroemer
Feb 21, 2021·Journal of Cellular and Molecular Medicine·Ying ChengCong Liu
Feb 27, 2021·Frontiers in Immunology·Zhou SheJidong Tian
Apr 28, 2020·Endocrine, Metabolic & Immune Disorders Drug Targets·Xuling LuoZhiwei Chen
Mar 12, 2021·Biochemistry. Biokhimii︠a︡·A Y AndreyevA A Starkov
Feb 10, 2021·Infection and Immunity·Kristin L Patrick, Robert O Watson
Oct 20, 2020·Current Opinion in Physiology·David M PatrickAnnet Kirabo

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