Mitochondria in the maintenance of hematopoietic stem cells: new perspectives and opportunities.

Blood
Marie-Dominique Filippi, Saghi Ghaffari

Abstract

The hematopoietic system produces new blood cells throughout life. Mature blood cells all derived from a pool of rare long-lived hematopoietic stem cells (HSCs) that are mostly quiescent but occasionally divide and self-renew to maintain the stem cell pool and to insure the continuous replenishment of blood cells. Mitochondria have recently emerged as critical not only for HSC differentiation and commitment but also for HSC homeostasis. Mitochondria are dynamic organelles that orchestrate a number of fundamental metabolic and signaling processes, producing most of the cellular energy via oxidative phosphorylation. HSCs have a relatively high amount of mitochondria that are mostly inactive. Here, we review recent advances in our understanding of the role of mitochondria in HSC homeostasis and discuss, among other topics, how mitochondrial dynamism and quality control might be implicated in HSC fate, self-renewal, and regenerative potential.

References

Feb 6, 2007·Experimental Gerontology·Derrick J RossiIrving L Weissman
Aug 3, 2007·The Journal of Clinical Investigation·Dragan MarinkovicSaghi Ghaffari
Mar 29, 2008·Cell Stem Cell·Kana MiyamotoAtsushi Hirao
Oct 8, 2008·Proceedings of the National Academy of Sciences of the United States of America·G M CereghettiL Scorrano
Jan 1, 2009·Advances in Experimental Medicine and Biology·Salvatore DiMauro, Michio Hirano
Dec 3, 2010·Nature·Sushma GurumurthyNabeel Bardeesy
Feb 23, 2011·The Journal of Experimental Medicine·Monika MortensenAnna Katharina Simon
Dec 6, 2011·Cell Death and Differentiation·E C FerberA Schulze
Mar 21, 2012·Proceedings of the National Academy of Sciences of the United States of America·Reto FiolkaMats G L Gustafsson
Mar 27, 2012·Nature Cell Biology·Maria MaryanovichAtan Gross
Sep 1, 2012·Science·Richard J Youle, Alexander M van der Bliek
Feb 5, 2013·Cell Reports·Katharine BrownDanica Chen
Apr 2, 2013·Cell·William G Kaelin, Steven L McKnight
Jan 5, 2014·Antioxidants & Redox Signaling·Raymond Liang, Saghi Ghaffari
Mar 22, 2014·Nature Reviews. Molecular Cell Biology·Keisuke Ito, Toshio Suda
May 31, 2014·Biochimica Et Biophysica Acta·Deborah Naon, Luca Scorrano
Sep 23, 2014·Nature Reviews. Molecular Cell Biology·Prashant Mishra, David C Chan
Nov 6, 2014·Development·Carolina L BigarellaSaghi Ghaffari
Apr 15, 2015·Proceedings of the National Academy of Sciences of the United States of America·Riccardo FiladiPaola Pizzo
Jul 26, 2015·EMBO Reports·Pauline RimmeléSaghi Ghaffari
Jul 30, 2015·Nature Communications·Maria MaryanovichAtan Gross

❮ Previous
Next ❯

Citations

Sep 10, 2020·The FEBS Journal·Taeko Kobayashi, Ryoichiro Kageyama
Oct 23, 2019·Nature Reviews. Molecular Cell Biology·Florian J Bock, Stephen W G Tait
May 14, 2020·Current Opinion in Hematology·Georgina A AndersonKatie L Kathrein
Sep 19, 2020·American Journal of Hematology·Katarzyna Mleczko-Sanecka, Laura Silvestri
Oct 28, 2020·The Journal of Clinical Investigation·Alhomidi AlmotiriNeil P Rodrigues
Nov 9, 2020·Molecular Aspects of Medicine·George HajishengallisTriantafyllos Chavakis
Mar 6, 2021·Cell Stem Cell·Ram Prosad Chakrabarty, Navdeep S Chandel
Mar 13, 2021·Blood Advances·Jiajing QiuSaghi Ghaffari
May 1, 2021·International Journal of Molecular Sciences·Makiko Mochizuki-KashioAyako Nakamura-Ishizu
Jul 22, 2020·Developmental Cell·Ayako Nakamura-IshizuToshio Suda
Sep 26, 2021·Leukemia·Lucie de BeauchampG Vignir Helgason
Oct 30, 2021·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·Cornelis J F van NoordenVashendriya V V Hira

❮ Previous
Next ❯

Related Concepts

Related Feeds

Adult Stem Cells

Adult stem cells reside in unique niches that provide vital cues for their survival, self-renewal, and differentiation. They hold great promise for use in tissue repair and regeneration as a novel therapeutic strategies. Here is the latest research.

Blood And Marrow Transplantation

The use of hematopoietic stem cell transplantation or blood and marrow transplantation (bmt) is on the increase worldwide. BMT is used to replace damaged or destroyed bone marrow with healthy bone marrow stem cells. Here is the latest research on bone and marrow transplantation.