PMID: 29764564May 17, 2018Paper

Mitochondria-mediated defense mechanisms against pathogens in Caenorhabditis elegans

BMB Reports
Sujeong KwonSeung-Jae V Lee

Abstract

Mitochondria are crucial organelles that generate cellular energy and metabolites. Recent studies indicate that mitochondria also regulate immunity. In this review, we discuss key roles of mitochondria in immunity against pathogen infection and underlying mechanisms, focusing on discoveries using Caenorhabditis elegans. Various mitochondrial processes, including mitochondrial surveillance mechanisms, mitochondrial unfolded protein response (UPRmt), mitophagy, and reactive oxygen species (ROS) production, contribute to immune responses and resistance of C. elegans against pathogens. Biological processes of C. elegans are usually conserved across phyla. Thus, understanding the mechanisms of mitochondria-mediated defense responses in C. elegans may provide insights into similar mechanisms in complex organisms, including mammals. [BMB Reports 2018; 51(6): 274-279].

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Citations

Jul 4, 2020·Toxicological Sciences : an Official Journal of the Society of Toxicology·Fuli ZhengMichael Aschner
Dec 29, 2020·Frontiers in Cellular and Infection Microbiology·Shirley Luckhart, Michael A Riehle
Jun 12, 2021·Disease Models & Mechanisms·Marlies P RossmannLeonard I Zon

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