Mitochondria-targeted antioxidant therapy with MitoQ ameliorates aortic stiffening in old mice.

Journal of Applied Physiology
Rachel A Gioscia-RyanDouglas R Seals

Abstract

Aortic stiffening is a major independent risk factor for cardiovascular diseases, cognitive dysfunction, and other chronic disorders of aging. Mitochondria-derived reactive oxygen species are a key source of arterial oxidative stress, which may contribute to arterial stiffening by promoting adverse structural changes-including collagen overabundance and elastin degradation-and enhancing inflammation, but the potential for mitochondria-targeted therapeutic strategies to ameliorate aortic stiffening with primary aging is unknown. We assessed aortic stiffness [pulse-wave velocity (aPWV)], ex vivo aortic intrinsic mechanical properties [elastic modulus (EM) of collagen and elastin regions], and aortic protein expression in young (~6 mo) and old (~27 mo) male C57BL/6 mice consuming normal drinking water (YC and OC) or water containing mitochondria-targeted antioxidant MitoQ (250 µM; YMQ and OMQ) for 4 wk. Both baseline and postintervention aPWV values were higher in OC vs. YC (post: 482 ± 21 vs. 420 ± 5 cm/s, P < 0.05). MitoQ had no effect in young mice but decreased aPWV in old mice (OMQ, 426 ± 20, P < 0.05 vs. OC). MitoQ did not affect age-associated increases in aortic collagen-region EM, collagen expression, or proinflammatory c...Continue Reading

References

Feb 15, 2000·Annals of the New York Academy of Sciences·R N Kalaria
Jan 1, 1997·ILAR Journal·Richard L. Sprott, Israel Ramirez
Apr 23, 2002·Hypertension·Mingyi Wang, Edward G Lakatta
Jul 31, 2002·Circulation·Scott W BallingerMarschall S Runge
Aug 7, 2002·Journal of Biomechanics·Dimitrios P SokolisPanayotis E Karayannacos
Jun 27, 2003·Canadian Journal of Applied Physiology = Revue Canadienne De Physiologie Appliquée·Toshiya NosakaMitsuo Matsuda
Aug 12, 2004·Free Radical Biology & Medicine·Kristin K Nelson, J Andres Melendez
Feb 26, 2005·Arteriosclerosis, Thrombosis, and Vascular Biology·Susan J ZiemanDavid A Kass
Apr 16, 2005·American Journal of Hypertension·Marie McNultyJohn Feely
Aug 17, 2005·Hypertension·Samer S NajjarEdward G Lakatta
Jan 4, 2007·The Journal of Pathology·S E Greenwald
Apr 10, 2007·American Journal of Physiology. Heart and Circulatory Physiology·Zoltan UngvariAnna Csiszar
Jul 5, 2008·Journal of Applied Physiology·Anna CsiszarZoltan Ungvari
Jul 29, 2008·American Journal of Physiology. Heart and Circulatory Physiology·Steven R LammersRobin Shandas
Jan 23, 2009·Biochimica Et Biophysica Acta·Vladimir P SkulachevDmitry B Zorov
Oct 27, 2009·Free Radical Biology & Medicine·Sergio Rodriguez-CuencaMichael P Murphy
Jan 13, 2010·The Journal of Trauma·Gregory K SteeleGary A Smith
Jan 20, 2010·Circulation·Gary F MitchellEmelia J Benjamin
Jan 27, 2010·The Mount Sinai Journal of Medicine, New York·Dara L DicksteinPatrick R Hof
Feb 24, 2010·Circulation·Donald Lloyd-JonesUNKNOWN American Heart Association Statistics Committee and Stroke Statistics Subcommittee
Jul 24, 2010·Annals of the New York Academy of Sciences·Robin A J Smith, Michael P Murphy
Jan 26, 2011·Circulation·Paul A HeidenreichUNKNOWN Council on Cardiovascular Surgery and Anesthesia, and Interdisciplinary Council on Quality of Care and Outcomes Research
May 31, 2011·American Journal of Physiology. Heart and Circulatory Physiology·Lisa A LesniewskiDouglas R Seals
Dec 20, 2011·Circulation·Véronique L RogerUNKNOWN American Heart Association Statistics Committee and Stroke Statistics Subcommittee
Dec 27, 2011·Arteriosclerosis, Thrombosis, and Vascular Biology·Rui-Hai ZhouMarschall S Runge
Jan 10, 2012·Gerontology·David R Sell, Vincent M Monnier
Feb 10, 2012·Yonsei Medical Journal·Sungha Park, Edward G Lakatta
Mar 1, 2012·Aging·Pat Monaghan
Apr 14, 2012·Circulation Research·Dao-Fu DaiZoltan Ungvari
May 10, 2012·Experimental Gerontology·Jochen SteppanDan E Berkowitz
May 10, 2012·The Journal of Physiology·Thomas J LaRoccaDouglas R Seals
Nov 13, 2012·Experimental Gerontology·Bradley S FleenorDouglas R Seals
Feb 26, 2013·Movement Disorders : Official Journal of the Movement Disorder Society·Stacey L KowalAnjali Jain
Dec 25, 2013·Trends in Endocrinology and Metabolism : TEM·Mingyi WangEdward G Lakatta
Mar 26, 2014·The Journal of Physiology·Rachel A Gioscia-RyanDouglas R Seals
May 27, 2014·Longevity & Healthspan·Dao-Fu DaiPeter S Rabinovitch

❮ Previous
Next ❯

Citations

Mar 17, 2018·Genes·Corina T Madreiter-SokolowskiWolfgang F Graier
Jul 22, 2018·American Journal of Physiology. Heart and Circulatory Physiology·Benard O OgolaSarah H Lindsey
Sep 14, 2018·Journal of Applied Physiology·Matthew J RossmanDouglas R Seals
Jan 17, 2019·Antioxidants & Redox Signaling·Gaston Ofman, Trent E Tipple
Feb 16, 2019·British Journal of Pharmacology·Jennifer J DuPontIris Z Jaffe
Jul 22, 2019·Experimental Physiology·Daniel W Trott, Paul J Fadel
Aug 21, 2019·Antioxidants·Egor Y Plotnikov, Dmitry B Zorov
Mar 18, 2020·Endocrine Reviews·Alexis Diaz-VegasSergio Lavandero
Jun 26, 2020·Clinical Science·Matthew J RossmanDouglas R Seals
Jul 25, 2020·American Journal of Physiology. Heart and Circulatory Physiology·Song-Young ParkIraklis I Pipinos
Mar 14, 2019·Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte·Maurizio ForteSperanza Rubattu
Jul 18, 2020·American Journal of Physiology. Heart and Circulatory Physiology·Theodore M DeConneChristopher R Martens
Aug 5, 2020·GeroScience·Arehally M MahalakshmiMeena Kishore Sakharkar
May 17, 2019·International Journal of Molecular Sciences·Shanna Hamilton, Dmitry Terentyev
May 31, 2020·Mechanisms of Ageing and Development·Maurizio ForteSperanza Rubattu
May 8, 2020·International Immunopharmacology·Yemane Tadesse DestaXiufang Weng
Jan 18, 2021·Free Radical Biology & Medicine·Guillermo López-Lluch
Apr 4, 2021·Antioxidants·Xiang-Qun Hu, Lubo Zhang
Apr 10, 2021·American Journal of Physiology. Heart and Circulatory Physiology·Danielle L KirkmanDavid G Edwards
Jun 12, 2021·American Journal of Physiology. Heart and Circulatory Physiology·Zachary S ClaytonDouglas R Seals
Jun 25, 2021·The Journal of Physiology·Daniel W TrottAnthony J Donato
Aug 27, 2021·Journal of Molecular and Cellular Cardiology·Yang-Nan DingDe-Pei Liu
Sep 14, 2021·Physiology·Paul B DieffenbachDaniel J Tschumperlin

❮ Previous
Next ❯

Methods Mentioned

BETA
ELISA
transgenic

Software Mentioned

SPSS
ImageJ
Cirasoft

Related Concepts

Related Feeds

Cardiovascular Inflammation

Inflammation plays a significant role in the development of cardiovascular diseases, an understanding of these endogenous processes is critical for evaluating the risks and potential treatment strategies. Discover the latest research on cardiovascular inflammation here.

Cardiovascular Disease Pathophysiology

Cardiovascular disease involves several different processes that contribute to the pathological mechanism, including hyperglycemia, inflammation, atherosclerosis, hypertension and more. Vasculature stability plays a critical role in the development of the disease. Discover the latest research on cardiovascular disease pathophysiology here.

Cell Aging

This feed focuses on cellular aging with emphasis on mitochondria, autophagy, and metabolic processes associated with aging and longevity. Here is the latest research on cell aging.

Cell Aging (Keystone)

This feed focuses on cellular aging with emphasis on the mitochondria, autophagy, and metabolic processes associated with aging and longevity. Here is the latest research on cell aging.

Aging-Associated Metabolic Disorders

Age is associated with many metabolic disorders including cardiovascular diseases, type 2 diabetes, stroke and heart disease. The mediators in aging process have been suggested to play a part in the cellular processes responsible for these metabolic disorders. Here is the latest research on aging-associated metabolic disorders.