Mitochondria: the cellular hub of the dynamic coordinated network

Antioxidants & Redox Signaling
Fei Yin, Enrique Cadenas

Abstract

Mitochondria are the powerhouses of the eukaryotic cell. After billions of years of evolution, mitochondria have adaptively integrated into the symbiont. Such integration is not only evidenced by the consolidation of genetic information, that is, the transfer of most mitochondrial genes into the nucleus, but also manifested by the functional recombination by which mitochondria participate seamlessly in various cellular processes. In the past decade, the field of mitochondria biology has been focused on the dynamic and interactive features of these semiautonomous organelles. Aspects of a complex multilayer quality control system coordinating mitochondrial function and environmental changes are being uncovered and refined. This Forum summarizes the recent progress of these critical topics, with a focus on the dynamic quality control of mitochondrial reticulum, including their biogenesis, dynamic remodeling, and degradation, as well as the homeostasis of the mitochondrial proteome. These diverse but interconnected mechanisms are found to be critical in the maintenance of a functional, efficient, and responsive mitochondrial population and could therefore become therapeutic targets in numerous mitochondrion-implicated disorders.

References

Mar 31, 2004·Molecular Aspects of Medicine·Enrique Cadenas
Jul 17, 2012·Antioxidants & Redox Signaling·Fei YinEnrique Cadenas
Dec 21, 2014·Antioxidants & Redox Signaling·Hao Wu, Quan Chen
Dec 30, 2014·Antioxidants & Redox Signaling·Surinder Kumar, David B Lombard
Dec 30, 2014·Antioxidants & Redox Signaling·Iryna BohovychOleh Khalimonchuk
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Jan 6, 2015·Antioxidants & Redox Signaling·Carlotta GiorgiPaolo Pinton
Jan 9, 2015·Antioxidants & Redox Signaling·Antonio ZorzanoJuan Pablo Muñoz

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Citations

Jan 21, 2016·FEBS Letters·Xue FuJie Yang
Aug 22, 2015·The Journal of Physiology·Fei YinEnrique Cadenas
Jul 31, 2016·Mechanisms of Ageing and Development·Silvia MaglioniNatascia Ventura
Sep 30, 2016·The International Journal of Biochemistry & Cell Biology·Silvina S BombicinoLaura B Valdez
Aug 6, 2019·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·Bérénice A Benayoun, Changhan Lee
May 1, 2020·British Journal of Pharmacology·Swayam Prakash SrivastavaDaisuke Koya
May 16, 2020·The Journal of Clinical Endocrinology and Metabolism·Laura JackischPhilip G McTernan
Jul 1, 2016·Clinical Science·Miguel A AonSteven J Sollott
Jan 11, 2017·Alcohol and Alcoholism : International Journal of the Medical Council on Alcoholism·Anthony A DuplantyPatricia E Molina
Sep 27, 2018·Cell Death & Disease·Swayam Prakash SrivastavaDaisuke Koya
Jul 14, 2017·Frontiers in Aging Neuroscience·Fei YinEnrique Cadenas
Jan 1, 2016·Fiziolohichnyĭ zhurnal·T V SerebrovskaE Egorov
Feb 9, 2018·Molecular Aspects of Medicine·Cesar G FragaMonica Galleano
May 14, 2021·IScience·Swayam Prakash SrivastavaDaisuke Koya
May 22, 2021·Frontiers in Immunology·Juan ZhaoZhi Q Yao
May 29, 2021·Frontiers in Cardiovascular Medicine·Yi LuZhejun Cai
May 9, 2016·ACS Biomaterials Science & Engineering·Shefang YeLei Ren

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Methods Mentioned

BETA
GTPases

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