Mitochondria to motion: optimizing oxidative phosphorylation to improve exercise performance

The Journal of Experimental Biology
Kevin E Conley

Abstract

Mitochondria oxidize substrates to generate the ATP that fuels muscle contraction and locomotion. This review focuses on three steps in oxidative phosphorylation that have independent roles in setting the overall mitochondrial ATP flux and thereby have direct impact on locomotion. The first is the electron transport chain, which sets the pace for oxidation. New studies indicate that the electron transport chain capacity per mitochondria declines with age and disease, but can be revived by both acute and chronic treatments. The resulting higher ATP production is reflected in improved muscle power output and locomotory performance. The second step is the coupling of ATP supply from O2 uptake (mitochondrial coupling efficiency). Treatments that elevate mitochondrial coupling raise both exercise efficiency and the capacity for sustained exercise in both young and old muscle. The final step is ATP synthesis itself, which is under dynamic control at multiple sites to provide the 50-fold range of ATP flux between resting muscle and exercise at the mitochondrial capacity. Thus, malleability at sites in these subsystems of oxidative phosphorylation has an impact on ATP flux, with direct effects on exercise performance. Interventions are...Continue Reading

References

Nov 15, 1991·Proceedings of the National Academy of Sciences of the United States of America·E R WeibelH Hoppeler
Mar 1, 1989·Proceedings of the National Academy of Sciences of the United States of America·K SchwerzmannE R Weibel
Aug 1, 1985·Journal of Applied Physiology·H HoppelerE R Weibel
May 1, 1969·Journal of Applied Physiology·B J Whipp, K Wasserman
Jan 1, 1984·Physiological Reviews·D G Nicholls, R M Locke
Oct 1, 1995·The Journal of Clinical Investigation·R S RichardsonP D Wagner
Jun 1, 1993·Respiration Physiology·D L TurnerG Ferretti
Sep 22, 1999·International Journal of Obesity and Related Metabolic Disorders : Journal of the International Association for the Study of Obesity·P SchrauwenW H Saris
Jul 6, 2000·The Journal of Physiology·K E ConleyP C Esselman
Jul 6, 2000·The Journal of Physiology·K E ConleyR B Schoene
Oct 29, 2000·Experimental Gerontology·M D Brand
Apr 12, 2001·Journal of Applied Physiology·S A JubriasK E Conley
Nov 22, 2001·Journal of Applied Physiology·R S RichardsonE A Noyszewski
Jan 1, 1956·Advances in Enzymology and Related Subjects of Biochemistry·B CHANCE, G R WILLIAMS
Jul 1, 1956·Journal of Gerontology·D HARMAN
Oct 3, 2003·American Journal of Physiology. Cell Physiology·David J MarcinekKevin E Conley
Dec 1, 2004·Acta Physiologica Scandinavica·M-E HarperJ J Ramsey
Mar 19, 2005·Journal of Applied Physiology·Edward F Coyle
Aug 6, 2005·The Journal of Experimental Biology·Paul J SchaefferStan L Lindstedt
Oct 26, 2005·Biochemical Society Transactions·M D Brand
Oct 29, 2005·The Journal of Physiology·David J MarcinekKevin E Conley
Dec 16, 2006·Experimental Physiology·Kevin E ConleyDavid J Marcinek
Jan 9, 2007·European Journal of Applied Physiology·V CettoloM P Francescato
Jan 12, 2007·Proceedings of the National Academy of Sciences of the United States of America·Catherine E AmaraKevin E Conley
Mar 17, 2007·Journal of Applied Physiology·Justus D Ortega, Claire T Farley
Apr 10, 2007·Exercise and Sport Sciences Reviews·Kevin E ConleyDavid J Marcinek
Jul 20, 2007·Acta Physiologica·F J LarsenB Ekblom
Dec 7, 2007·Applied Physiology, Nutrition, and Metabolism = Physiologie Appliquée, Nutrition Et Métabolisme·Sheila R CostfordMary-Ellen Harper
Dec 20, 2007·Current Opinion in Clinical Nutrition and Metabolic Care·Kevin E ConleyJason Villarin
Oct 22, 2008·Proceedings of the National Academy of Sciences of the United States of America·Douglas E BefroyGerald I Shulman
Jul 23, 2009·American Journal of Physiology. Endocrinology and Metabolism·Jeroen A L JenesonJeanine J Prompers
May 25, 2010·Free Radical Biology & Medicine·Laurence J Toime, Martin D Brand
Feb 25, 2011·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Tibor HortobágyiPaul DeVita
May 11, 2011·The Biochemical Journal·Christopher G R PerryP Darrell Neufer
Jul 29, 2011·The Journal of Experimental Biology·Frank E NelsonMartin J Kushmerick
Sep 1, 2012·Mechanisms of Ageing and Development·Michael P SiegelDavid J Marcinek
Oct 12, 2012·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Paul M CoenBret H Goodpaster
Oct 23, 2012·Experimental Physiology·Kevin E ConleyPeter Esselman
Jan 15, 2013·Trends in Cardiovascular Medicine·Sheng-Bing WangJennifer E Van Eyk

❮ Previous
Next ❯

Citations

Mar 1, 2016·Journal of Comparative Physiology. B, Biochemical, Systemic, and Environmental Physiology·Loïc TeulierDamien Roussel
Apr 30, 2017·The Journal of Experimental Biology·Aurore BourguignonDamien Roussel
May 29, 2019·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Matteo FiorenzaMorten Hostrup
Oct 31, 2019·The Journal of Physiological Sciences : JPS·Tetsuya ShiuchiHiroyoshi Séi
Dec 13, 2017·Current Opinion in Clinical Nutrition and Metabolic Care·Danielle E BearZudin A Puthucheary
Nov 13, 2019·Scientific Reports·Emily BusseMimi Sammarco
Jul 20, 2019·Oxidative Medicine and Cellular Longevity·Jesus R HuertasSara Cogliati
Jul 23, 2020·Nature Metabolism·James FramptonEdward S Chambers
Oct 19, 2017·Ecotoxicology·Juan WangQisheng Song
Oct 19, 2019·The Journal of Experimental Biology·Manfred R EnstippYves Handrich
Feb 12, 2020·The Journal of Experimental Biology·Mélanie BoëlYann Voituron
Nov 10, 2020·Biological Reviews of the Cambridge Philosophical Society·Kang Nian YapWendy R Hood
Jan 21, 2021·Journal of Functional Morphology and Kinesiology·Andrew E PechsteinAndrew A Guccione
Apr 16, 2020·Free Radical Biology & Medicine·Doria BoulghobraCyril Reboul
Jun 10, 2021·Phytomedicine : International Journal of Phytotherapy and Phytopharmacology·Kenneth Kin Leung KwanKarl Wah Keung Tsim

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

The Journal of Experimental Biology
Sarah Kuzmiak-Glancy, Wayne T Willis
The Journal of Experimental Biology
H Hoppeler, E R Weibel
© 2022 Meta ULC. All rights reserved