Mitochondrial abnormalities in Parkinson's disease and Alzheimer's disease: can mitochondria be targeted therapeutically?

Biochemical Society Transactions
Ruby MacdonaldHeather Mortiboys

Abstract

Mitochondrial abnormalities have been identified as a central mechanism in multiple neurodegenerative diseases and, therefore, the mitochondria have been explored as a therapeutic target. This review will focus on the evidence for mitochondrial abnormalities in the two most common neurodegenerative diseases, Parkinson's disease and Alzheimer's disease. In addition, we discuss the main strategies which have been explored in these diseases to target the mitochondria for therapeutic purposes, focusing on mitochondrially targeted antioxidants, peptides, modulators of mitochondrial dynamics and phenotypic screening outcomes.

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Citations

Jun 24, 2020·Alzheimer's & Dementia : the Journal of the Alzheimer's Association·Richard ShervaRobert C Green
Sep 24, 2020·International Journal of Molecular Sciences·Carmen Martínez-Cué, Noemí Rueda
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Jan 3, 2021·Cellular and Molecular Neurobiology·Fillipe M de AraújoMaria Trinidad Herrero
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Dec 1, 2020·Frontiers in Neuroscience·Xu YanXinwen Zhang
Jan 15, 2021·Biomedicines·Simon M BellHeather Mortiboys
Nov 26, 2019·Current Medicinal Chemistry·Olakunle OladimejiMoganavelli Singh
Sep 25, 2020·Scientific Reports·Aurelie SchwartzentruberHeather Mortiboys
May 8, 2021·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Karolina DrabikJoanna Szczepanowska
Jun 3, 2021·International Journal of Molecular Sciences·Chanchal SharmaSang Ryong Kim
Jul 14, 2021·Omics : a Journal of Integrative Biology·Sayali Chandrashekhar DeolankarThottethodi Subrahmanya Keshava Prasad
Nov 10, 2021·Current Opinion in Rheumatology·Mercedes Fernández-MorenoFrancisco J Blanco
Jan 18, 2022·Signal Transduction and Targeted Therapy·Huiyuan ZhuHuanlong Qin

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