Mitochondrial accumulation of doxorubicin in cardiac and diaphragm muscle following exercise preconditioning

Mitochondrion
Aaron B MortonAshley J Smuder

Abstract

Doxorubicin (DOX) is a highly effective anthracycline antibiotic. Unfortunately, the clinical use of DOX is limited by the risk of deleterious effects to cardiac and respiratory (i.e. diaphragm) muscle, resulting from mitochondrial reactive oxygen species (ROS) production. In this regard, exercise is demonstrated to protect against DOX-induced myotoxicity and prevent mitochondrial dysfunction. However, the protective mechanisms are currently unclear. We hypothesized that exercise may induce protection by increasing the expression of mitochondria-specific ATP-binding cassette (ABC) transporters and reducing mitochondrial DOX accumulation. Our results confirm this finding and demonstrate that two weeks of exercise preconditioning is sufficient to prevent cardiorespiratory dysfunction.

Citations

Jan 11, 2019·Medicine and Science in Sports and Exercise·J Matthew HinkleyAshley J Smuder
Aug 29, 2019·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Ashley J Smuder
Nov 28, 2019·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Ryan N MontalvoAshley J Smuder
Oct 4, 2020·International Journal of Molecular Sciences·Ashley J SmuderDavid D Fuller
Nov 15, 2018·Pflügers Archiv : European journal of physiology·Scott K PowersHayden Hyatt
Sep 29, 2020·Frontiers in Physiology·Brandon N VanderVeenJames A Carson
Dec 29, 2020·Frontiers in Physiology·Brandon N VanderVeenE Angela Murphy
Nov 5, 2020·International Journal of Molecular Sciences·Ryan N MontalvoAshley J Smuder
Jan 28, 2020·Medicine and Science in Sports and Exercise·Andres Mor HuertasAshley J Smuder
Feb 25, 2020·Redox Biology·Scott K PowersHayden Hyatt
Jul 25, 2021·Cancers·Dean G CampeljEmma Rybalka

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