Mitochondrial Acetyl-CoA Synthetase 3 is Biosignature of Gastric Cancer Progression

Cancer Medicine
Wei-Chun ChangWen-Lung Ma

Abstract

Cholesterol affects cancer progression, and acetyl-CoA is the primary cholesterogenesis substrate. The previous work has defined cholesterol bioflux via lipoprotein/receptor route is the gastric cancer (GCa) prognosis biosignature. The prognosis importance of acetyl-CoA to cholesterogenesis (mevalonate pathway) in GCa is yet to be defined. Using Kaplan-Meier Plotter web-based gene survival analyzer and The Cancer Genome Atlas (TCGA)-database analyzed with DBdriver.v2 platform, we revealed acetyl-CoA production and the mevalonate pathway are associated with GCa prognosis. We found mitochondrial-derived acetyl-CoA contributing enzymes (acyl-coA synthetase super-family 3; ACSS3) is the GCa progression confounder. Interestingly, it is not HMGCR (the committee enzyme of mevalonate pathway), but lower mevalonate pathway enzymes (e.g., MVK, LSS, DHCR14A1, SC4MOL, HSD17B7, SC5D) promote GCa patients 5-years overall survival in a differential level. Advanced analyses found ACSS3 is prognosis biosignatures for multiple GCa disease conditions. This report uncovered a higher expression of ACSS3 in tumor comparing to normal parental lesions, which implicates a targeting value for GCa therapy. While knockdown ACSS3 could suppress growth and ...Continue Reading

References

Nov 30, 2006·International Journal of Cancer. Journal International Du Cancer·Danielle R L Browning, Richard M Martin
Sep 1, 2007·Journal of Lipid Research·Paul A WatkinsJonathan Pevsner
Jul 21, 2009·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·Mijin YunJong Doo Lee
Aug 24, 2010·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Inge R H M KoningsStefan Sleijfer
Jun 28, 2011·Gut·William H AllumUNKNOWN Association of Upper Gastrointestinal Surgeons of Great Britain and Ireland, the British Society of Gastroenterology and the
Dec 17, 2011·BMC Bioinformatics·Qiyuan LiAron C Eklund
Feb 10, 2012·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Wen-Lung MaChawnshang Chang
Mar 28, 2013·Molecular Carcinogenesis·Lei CuiJianxin Zhang
Aug 13, 2013·PloS One·Ilaria BellezzaAlba Minelli
Nov 12, 2013·Nucleic Acids Research·Wei-Chung ChengHsei-Wei Wang
Feb 25, 2014·Molecular Cell·Guillermo MariñoGuido Kroemer
Jul 24, 2014·The Journal of Biological Chemistry·Lia R EdmundsEdward V Prochownik
Sep 15, 2014·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Seung Tae KimWon Ki Kang
Sep 23, 2014·Science·Douglas R GreenGuido Kroemer
Oct 17, 2014·World Journal of Gastroenterology : WJG·Marcus Foo, Trevor Leong
Nov 5, 2014·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Guo-Dong LuShing Chuan Hooi
Jun 16, 2015·Gastroenterology·Patrick Tan, Khay-Guan Yeoh
Aug 8, 2015·Journal of Cellular Biochemistry·Diane M JaworskiJohn R Moffett
Aug 12, 2015·Nature Reviews. Clinical Oncology·Sri G ThrumurthyWilliam Allum
Sep 19, 2015·Journal of Surgical Oncology·Hoon HurDakeun Lee
Dec 5, 2015·Nucleic Acids Research·I-Fang ChungWei-Chung Cheng
Dec 15, 2015·Cell Reports·Elias BjörnsonAdil Mardinoglu
Jun 9, 2016·Nature Immunology·Murali K AkulaDonghai Wang
Oct 25, 2016·Nature Reviews. Cancer·Peter J MullenLinda Z Penn

❮ Previous
Next ❯

Citations

Sep 27, 2019·Journal of Cellular and Molecular Medicine·Juan-Cheng YangWen-Lung Ma
Jun 17, 2020·Journal of Cellular and Molecular Medicine·Lumin ChenWei-Chun Chang
Dec 1, 2020·Expert Review of Gastroenterology & Hepatology·Yiming HaoYiqin Wang
Jan 1, 2021·PLoS Genetics·Katarina CisarovaCarlo Rivolta

❮ Previous
Next ❯

Methods Mentioned

BETA
FCS
flowcytometry
acetylation
histone acetylation
biopsy

Software Mentioned

NIS Elements
DriverDB
KM plotter analyzer
KM plotter
FlowJo

Related Concepts

Related Feeds

ApoE, Lipids & Cholesterol

Serum cholesterol, triglycerides, apolipoprotein B (APOB)-containing lipoproteins (very low-density lipoprotein (VLDL), immediate-density lipoprotein (IDL), and low-density lipoprotein (LDL), lipoprotein A (LPA)) and the total cholesterol/high-density lipoprotein (HDL) cholesterol ratio are all connected in diseases. Here is the latest research.