Mitochondrial activities of a cell line derived from thyroid Hürthle cell tumors

Thyroid : Official Journal of the American Thyroid Association
Karmen StankovG Lenaz

Abstract

We conducted a study on the functional characteristics of mitochondria in an oxyphilic thyroid tumor cell line, which may provide useful clues about Hürthle cell tumors carcinogenesis. The functional study on thyroid tumors with cell oxyphilia (Hürthle cell tumors), characterized by mitochondrial hyperplasia, was carried out in XTC.UC1, and B-CPAP, an oxyphilic and nonoxyphilic thyroid tumor cell line, respectively. XTC.UC1 cell line showed higher activity of mitochondrial respiratory complexes I and II and decreased activity of complex III. The increased activity of complex I was not matched by increased expression of complex I subunits. The XTC.UC1 cells relied mostly on oxidative phosphorylation for energy conservation, although their mitochondrial energetic function was less efficient when related to mitochondrial content of the cells. Finally, the oxyphilic cell line produced significantly higher amounts of reactive oxygen species (ROS) in comparison with B-CPAP cell line. The involvement of ROS in mitochondrial biogenesis and proliferation as well as in carcinogenesis and apoptosis indicate that differences in activity of respiratory chain components and their unbalance may be responsible for development of morphological ...Continue Reading

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Citations

Sep 11, 2009·Antioxidants & Redox Signaling·Giorgio Lenaz, Maria Luisa Genova
Jan 22, 2013·Mitochondrion·María J López-ArmadaMarta N Valcárcel-Ares
Aug 28, 2009·The International Journal of Biochemistry & Cell Biology·Giorgio Lenaz, Maria Luisa Genova
May 9, 2007·Mitochondrion·Giorgio LenazMaria Luisa Genova
Oct 13, 2011·BioFactors·Maria Luisa Genova, Giorgio Lenaz
Jan 24, 2006·Cancer Letters·Karmen StankovGiovanni Romeo
Dec 23, 2014·Oncology Reports·Antonella CormioMaria Nicola Gadaleta
Mar 27, 2012·Biochimica Et Biophysica Acta·Mark W PellegrinoCole M Haynes
Oct 27, 2017·Endocrine-related Cancer·Willem E CorverHans Morreau
Mar 19, 2020·Journal of Clinical Medicine·Sonia MissiroliCarlotta Giorgi
Apr 10, 2018·Frontiers in Oncology·Raquel Guimaraes CoelhoDenise P Carvalho
Oct 18, 2016·Oncology Reports·Raquel Guimarães CoelhoDenise P Carvalho
Mar 7, 2021·International Journal of Molecular Sciences·Jinwei HuXiangpeng Yuan

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