Mitochondrial activity and oxidative stress functions are influenced by the activation of AhR-induced CYP1A1 overexpression in cardiomyocytes

Molecular Medicine Reports
Bing ZhouWuhong Tan

Abstract

There is an endemic cardiomyopathy currently occurring in China, termed, Keshan disease (KD). The authors previously compared mitochondrial‑associated gene expression profiles of peripheral blood mononuclear cells (PBMCs) derived from KD patients and normal controls, using mitochondria‑focused cDNA microarray technology. The results detected an upregulation of the enzyme‑associated CYP1A1 gene, (ratios ≥2.0). The aryl hydrocarbon receptor (AhR) regulates the expression of numerous cytochrome P450 (CYP) genes including members of the CYP1 family; CYP1A1 and CYP1A2. Several previous studies have suggested roles for the aryl hydrocarbon receptor (AhR) and the genes that it regulates. An example involves cytochrome P4501A1 (CYP1A1), in the pathogenesis of heart failure, cardiac hypertrophy and other cardiomyopathies. Mitochondria comprise ~30% of the intracellular volume in mammalian cardiomyocytes, and subtle alterations in mitochondria can markedly influence cardiomyopathies. The present study investigated alterations in the activity and functions of mitochondria following AhR‑induced overexpression of CYP1A1. AC16 cells were treated with the CYP1A1 inducer 2,3,7,8‑tetrachlorodibenzo‑p‑dioxin (TCDD), and cytotoxicity was then eva...Continue Reading

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Citations

Jul 22, 2018·Current Medicinal Chemistry·Aysegul HanikogluTomris Ozben
Jan 25, 2020·American Journal of Physiology. Heart and Circulatory Physiology·Justyna SzostakJulia Hoeng
Aug 23, 2019·International Journal of Molecular Sciences·George Anderson, Gianluigi Mazzoccoli
Dec 29, 2020·Ecotoxicology and Environmental Safety·Zhang YimingLi Shu
Jan 24, 2021·Archives of Pharmacal Research·Yeo-Jung KwonYoung-Jin Chun
Feb 18, 2020·Neuroscience Letters·Chang Ho LeeSo Young Kim
Nov 3, 2021·Journal of Cachexia, Sarcopenia and Muscle·Trace ThomeRussell T Hepple

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Methods Mentioned

BETA
flow cytometry

Software Mentioned

SPSS
ImageJ

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